The role of immunocompetent cells and cytokine network in the cystic and bone resorption.

用免疫组织化学方法检测了15例牙源性角化囊肿和5例根状囊肿的颌壁和3例成釉细胞瘤结缔组织包膜中免疫活性细胞的分布。识别CD4^+/CD8^+T淋巴细胞的抗体UCHL-1在囊肿壁上皮下炎性病变中强烈表达。在未发炎的囊肿壁，uchl -1阳性细胞倾向于定位于靠近骨的最外层区域。KP1抗体在纤维壁血管周围区域和炎症灶中检测到广泛的单核-巨噬细胞谱系。在骨组织中，新形成的骨周围的单核细胞和破骨细胞似乎表达这种抗体。在骨旁纤维组织中，特别是血管周围区域的细胞中，观察到针对常驻巨噬细胞的HAM56抗体。骨组织中单个核细胞也表达HAM56抗体，但其数量少于kp1阳性细胞，且无破骨细胞表达该抗体。MAC387可识别具有抗原L1的白细胞，在炎症灶和部分上皮内强烈表达，但在纤维囊肿壁和骨组织中未见表达。从迄今为止的结果来看，可以推测免疫活性细胞的分布与囊性病变的生长之间存在一定的关系。

The distribution of immunocompetent cells in the wall of jaw cysts (15 odontogenic keratocysts and 5 radicular cysts) and the connective tissue capsule of 3 ameloblastomas were examined immunohistochemically.1.The antibody UCHL-1, which recognized CD4^+/CD8^+T lymphocytes, was intensely expressed in the subepithelial inflammatory lesion of the cyst wall. In the non-inflamed cyst wall, UCHL-1-positive cells tended to be localized in the outermost area adjacent to the bone.2.KP1 antibody which recognized a wide range of monocyte-macrophage lineage was observed in the perivascular area of fibrous wall as well as inflammatory foci. In the bone tissue, mononuclear cells around the newly formed bone and osteoclasts appeared to expressed this antibody.3.HAM56 antibody for resident macrophages was observed in the fibrous tissue adjacent to the bone, particularly the cells in the perivascular area. Mononuclear cells in the bone tissue also expressed HAM56 antibody, but they were fewer than KP1-positive cells and no osteoclasts expressed this antibody.4.MAC387 which recognized leukocytes having antigen L1 was intensely expressed in the inflammatory foci and a part of lining epithelium but no expression was discernible in the fibrous cyst wall and bone tissue.From the results to date it is presumed that there is a certain relationship between the distribution of immunocompetent cells and growth of the cystic lesion.