The Histopathological Study of Guided tissue Regeneration Technique Using the Periosteum-hybridized Resorbable Barrier Membrane.

1.第一项研究表明，与仅使用PTFE膜的传统技术相比，通过杂交自体骨膜获得的PTFE膜的应用加速牙周再生。实验2、骨膜杂交的FC-HAC能促进骨缺损的修复;实验3、实验4、实验5、实验6、实验7、实验10、实验11、实验12、实验13、实验14、实验15、实验16、实验17、实验18、实验19、实验19与自体骨膜组织对牙周组织再生的影响，试图通过常规GTR方法在开窗型骨缺损的比格犬模型中促进牙周组织再生。发现H-PLA膜植入组中的新骨形成和新牙骨质形成均比对照（C-PLA）植入组中的新骨形成和新牙骨质形成显著更促进。两组均未观察到骨性关节强直。4.第四项研究，我们在实验动物中进行了评价，以确定将脱氢热（DHT）交联胶原海绵与自体骨膜杂交和DHT交联胶原涂层乳酸-乙醇酸共聚物膜结合的方法是否有效（C-PLA膜）在GBR方法中作为在具有开裂型骨缺损的无牙区进行骨内植入的手段是有效的。提示该方法在GBR治疗局部骨缺损中有一定的应用价值。

1.The first study suggest that aplication of the PTFE membrane obtaind by hybridizing the autologous periosteum accelerates periodontal regeneration in comparison with the conventional technique employing the PTFE membrane alone. It was also suggested that bone and periosteal cells as well as periodontal ligament cells are significantly involved in new cement formation.2.The second study was thus concluded that implantation of the periosteum-hybridized FC-HAC significantly promoted the repair of bone defects.3.The third study we assessed the effect of poly-lactic acid membrane hyblidized (H-PLA) with autologous periosteal tissue on the regeneration of periodontal tissue in an attempt to promote periodontal tissue regeneration by the conventional GTR method in a beagle dog model of a fenestration-type bone defect. Both new bone formation and new cementum formation were found to have been significantly more promoted in the H-PLA membrane implanted group than in the control (C-PLA) implanted group. No osseous ankylosis was observed in either group.4.The fourth study, we conducted an evalution in experimental snimals to determine whether a method combining dehydrotherm-ally (DHT) crosslinking collagen sponge hybridized with autologous perosteum and DHT crosslinking collagen-coated lactic acid-glycolic acid copolymer membrane (C-PLA membrane) would be effective in the GBR method as a means of performing intraosseus implantation in an edentulous area with a dehiscence-type bone defect. The rezurts suggest that this method will be useful in the GBR method of treating local bone defects.