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Salt sensitivity and genetics in essential hypertension

原发性高血压的盐敏感性和遗传学

基本信息

批准号：
06672293
负责人：
OSHIMA Tetsuya
金额：
$ 1.15万
依托单位：
HIROSHIMA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06672293/
关键词：
Sodium Hypertension Genetics Angiotensin-converting enzyme Haptoglobin 食塩感受性遺伝的多型性

项目摘要

1.The present study was undertaken in 66 Japanese patients with mild essential hypertension to identify genetic factors associated with blood pressure of sodium chloride sensitivity. These subjects were classified into salt-sensitive or salt-resistant groups on the basis of changes in their mean blood pressure from a week of a low NaCl deit (50 mmol/day) to a week of a high NaCl diet (340 mmol/day).2.Salt sensitivity and resistance were studied in relation to a 287 bp insertion/deletion (I/D) polymorphism of the angiotensin I converting enzyme gene detected by a polymerase chain reaction method and the haptoglobin phenotype determined by polyacrylamide-gel electrophoresis.3.Patients with the angiotensin I converting enzyme gene genotype II were more apt to be salt-sensitive than patients with the ID and DD genotypes, although age, gender and plasma renin activity were similar in each group. The frequency of the I allele in the salt-sensitive group was significantly higher than that in the salt-resistant group (X^2=7.4, Odds ratio=2.78). However, there was no significant relationship between the haptoglobin phenotype and salt sensitivity.4.These date suggest that an I/D polymorphism of the angiotensin I converting enzyme gene is a genetic factor that are associated with sodium chloride sensitivity of blood pressure independently of gender, age and plasma renin activity in Japanese patients with essential hypertension.

1.本研究对 66 名日本轻度原发性高血压患者进行了研究，以确定与氯化钠敏感性血压相关的遗传因素。根据从一周低氯化钠饮食（50 mmol/天）到一周高氯化钠饮食（340 mmol/天）平均血压的变化，将这些受试者分为盐敏感组或盐抗性组。 2.研究了盐敏感性和盐耐受性与血管紧张素 I 转换的 287 bp 插入/删除 (I/D) 多态性的关系。聚合酶链式反应法检测酶基因，聚丙烯酰胺凝胶电泳测定触珠蛋白表型。3.血管紧张素I转换酶基因II型患者比ID和DD基因型患者更容易出现盐敏感，尽管各组年龄、性别和血浆肾素活性相似。盐敏感组中I等位基因的频率显着高于耐盐组（X^2=7.4，Odds比=2.78）。然而，触珠蛋白表型和盐敏感性之间没有显着关系。4.这些数据表明，血管紧张素I转换酶基因的I/D多态性是与日本原发性高血压患者的血压氯化钠敏感性相关的遗传因素，与性别、年龄和血浆肾素活性无关。