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Evaluation of the metabolisms of calcium and magnesium in the cardiovascular diseases

心血管疾病中钙、镁代谢的评价

基本信息

批准号：
08457639
负责人：
OSHIMA Tetsuya
金额：
$ 4.86万
依托单位：
HIROSHIMA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1997
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08457639/
关键词：
Calcium Magnesium Hypertension Angina Pectoris Arrythmia Diabetes Mellitus Platelets Erythrocytes 高脂血症尿中排泄量

项目摘要

1. Although the deficiency of Ca or Mg has been suggeested to be associated with the cardiovascular diseases, the appropriate evaluation of the metabolism of these cations is not established. In the present study, we determined whether there is an abnormality in the systemic or cellular metabolism of Ca orMg in several cardiovascular diseases.2. In patients with arrythmia, serum ionized Mg^<2+> concentration was reduced, whereas serum concentrations of total Ca and total Mg, and erythrocyte Mg concentration were normal.3. In patients with coronary artery diseases, such as myocardial infarction, effort angina and vasospastic angina, serum concentrations of Ca^<2+> and Mg^<2+>, and erythrocyte Mg concentration were normal.4. In patients with essential hypyertension, while serum concentrations of Ca^<2+> and Mg^<2+> were normal, [Mg^<2+>] i in platelets and erythrocytes, and Mg retention were increased.5. In patients with diabetes mellitus, serum ionized Mg^<2+> concentration was decreased, while serum concentrations of Ca^<2+> and total Mg and erythrocyte Mg were normal.6. All the indices were normal in patients with hyperlipidemia.7. Although serum concentration of total Ca and total Mg were normal in the cardiovascular diseases, serum ionized Mg^<2+> was reduced in diabetes mellitus and arrythmia, and intracellular Mg concentration was increased in essential hypertension.

1.虽然钙或镁的缺乏已被证实与心血管疾病有关，但对这些阳离子代谢的适当评价尚未建立。在本研究中，我们确定了在几种心血管疾病中是否存在钙或镁的全身或细胞代谢异常。心律失常患者血清离子型Mg^<2+>浓度降低，血清总Ca、总Mg浓度及红细胞Mg浓度正常.心肌梗死、劳力性心绞痛、血管痉挛性心绞痛等冠心病患者血清Ca^2+、Mg^2+浓度及红细胞Mg浓度均正常.原发性高血压患者在血清Ca^<2+>、Mg^<2+>浓度正常的情况下，血小板和红细胞内[Mg^<2+>] i增加，Mg潴留增加.糖尿病患者血清离子型Mg^<2+>浓度降低，而血清Ca^<2+>、总Mg和红细胞Mg浓度正常.高血压患者各项指标均正常.虽然心血管疾病患者血清总Ca和总Mg浓度正常，但糖尿病和心律失常患者血清离子Mg^<2+>降低，原发性高血压患者细胞内Mg浓度升高。