Expectation-induced enhancement of treatment effects on pain, itch and quality of life in psoriasis patients (A12)

期望诱导增强牛皮癣患者疼痛、瘙痒和生活质量的治疗效果 (A12)

• 批准号: 444751414
• 金额: --
• 依托单位: Institut für Medizinische Psychologie und Verhaltensimmunbiologie
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/444751414?language=en
• 关键词: Expectation; induced; enhancement; treatment; effects

We will systematically modulate treatment expectation in psoriasis patients undergoing treatment with the anti-IL-17A monoclonal antibody secukinumab in a clinical proof-of-concept trial. We will determine the effects of expectation induced by verbal instruction on treatment outcomes at the subjective (e.g., pain, itch, quality of life) and physiological (e.g., skin lesions) levels and will analyze whether and to what extent such strategy can be employed to reduce the treatment dosage.

我们将在临床概念验证试验中系统地调节接受抗 IL-17A 单克隆抗体苏金单抗治疗的银屑病患者的治疗预期。我们将确定口头指导引起的期望对主观（例如疼痛、瘙痒、生活质量）和生理（例如皮肤病变）水平的治疗结果的影响，并将分析是否以及在多大程度上可以采用这种策略来减少治疗剂量。