Confocal Laser Scanning Microscope (CLSM)

2007年，马尔堡菲利普斯大学生物系成立了先进光学显微镜中心（CALM）作为一个独立的附属设施，被列为菲利普斯大学的主要研究仪器单位。CALM的两台共聚焦显微镜被生物系的10个小组广泛使用，涉及这些CLSM设备的研究在过去五年中已经产生了50多篇论文，其中部分是高排名的论文。在过去两年中，生物系聘请了几位新教师，申请人是Großhans（2019年10月），Helker（2018年10月）和Voll（2017年10月）是三个对共焦成像机器时间有相当大需求的PI。这增加了目前估计的整体CLSM时间在该部门约7000小时，每年。该部门的许多小组的研究重点依赖于基于CLSM的细胞器，细胞和组织水平上的过程的结构和功能分析。共聚焦激光扫描显微镜（CLSM）领域的技术进步现在提供了具有改进的时间，空间和光谱分辨率的应用程序，这为在CALM操作现代CLSM设备提供了额外的论据，以促进生物学系的最先进的研究。

In 2007, the Department of Biology of the Philipps-University Marburg founded the Center of Advanced Light Microscopy (CALM) as a subsistent and subsidiary facility, which is classified as a Major Research Instrumentation unit of the Philipps-University. The two confocal microscopes of the CALM are intensively being used by 10 groups of the department biology and research involving these CLSM devices has led to more than 50, in part high-ranked, publications in the past five years.Several new faculty have been hired at the Department of Biology in the last two years, with the applicants Großhans (October 2019), Helker (October 2018) and Voll (October 2017) being three PIs with a considerable demand for confocal imaging machine time. This increases the current estimate for overall CLSM time at the department to about 7000 hours per year. The research focus of many groups at the department relies on CLSM-based structural and functional analysis of processes on the organellar, cellular and tissue level. Technological progress in the field of confocal laser scanning microscopy (CLSM) now offers applications with improved temporal, spatial and spectral resolution, which provides additional arguments for operating modern CLSM devices at the CALM in order to foster state-of-the-art research at the Department of Biology.