MONITORING AND ACTIVE CONTROL OF HEAT AND MASS TRASFER IN MICRO- AND NANOSCALE

微米级和纳米级传热传质的监测和主动控制

基本信息

批准号：
15206024
负责人：
HISHIDA Koichi
金额：
$ 31.37万
依托单位：
KEIO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15206024/
关键词：
Micro- and Nanoscale Micro-TAS Monitoring of interface molecules NMR Self-diffusion coefficient Nano Particles Selctive Separation Acoustic Radiation Pressure 選択的粒子分離脱プロトン反応 pH エバネッセント光界面動電駆動流

项目摘要

Rapid progress in microtechnology has yielded microfluidic devices that comprise microchannel networks for chip-based biological analyses handling small fluid sample volumes. For further development of micro devices, the in-situ monitoring and feedback control system is strongly required. The present study focused on development of monitoring system of interface molecules consisting of the small-scale planar surface coil and nuclear magnetic resonance detection system, a measurement technique of ion diffusion and transport in a microchannel and selective separation techniques of nanoscale particles. Summary of the results is shown as bellow. An interface monitoring system of water molecules was constructed by small-scale planar surface coils and nuclear magnetic resonance detection technique. Using this system, the dependence of T2(CPMG) relaxation time measured by CPMG method on water content in polymer electrolyte membrane (PEM) as a porous media was observed. In addition, using the … More pulse-field-gradient spin echo method as a pulse sequence in the interface monitoring system, the relationship between self-diffusion coefficient of water molecular and water content and temperature in the PEM was obtained. The accuracies of T2(CPMG) relaxation measurement and self-diffusion coefficient measurement using the small-scale planar surface coils were evaluated. Velocity and pH in microspace that are responsible for chemical reaction and mixing were measured by micron-resolution particle image velocimetry with a high spatial resolution. The zeta-potential of particles and microchannel wall was affected by varing pH, which was confirmed by measurement of electrophoretic velocity of submicron particles and electroosmotic velocity in a microchannel. A selective separation technique of submicron particles was developed by generating the conductivity gradient in a microchannel, inducing a control of electroosmotic velocity and an electrophoretic force acting on particles. Moreover, a continuous separation technique of suspended particles was proposed by utilizing an acoustic radiation force and an electrostatic force, which realized the particle separation taking into account size difference. Less

微技术的快速进步产生了微流体设备，包括用于基于芯片的生物学分析的微通道网络，可处理小流体样品体积。为了进一步开发微设备，强烈需要原位监视和反馈控制系统。本研究的重点是开发界面分子的监测系统，这些界面分子由小规模的平面表面线圈和核磁共振检测系统组成，这是一种在微通道中的离子扩散和传输的测量技术，以及纳米级颗粒的选择性分离技术。结果的摘要显示为波纹管。水分子的界面监测系统是由小规模的平面表面线圈和核磁共振检测技术构建的。使用该系统，观察到通过CPMG方法测量的T2（CPMG）松弛时间对聚合物电解质膜（PEM）中水含量作为多孔培养基的依赖性。此外，使用…更多的脉冲现场梯度自旋回波方法作为界面监测系统中的脉冲序列，获得了水分子的自扩散系数与PEM中水分含量和温度之间的关系。评估了使用小规模的平面表面线圈的T2（CPMG）松弛测量和自扩散系数测量的精度。通过微小分辨率粒子图像速度测量，用高空间分辨率测量了负责化学反应和混合的微层的速度和pH值。颗粒和微通道壁的Zeta势受到变化的pH影响，这通过测量亚微颗粒的电泳速度和微通道中的电泳速度证实。通过在微通道中产生电导率梯度，诱导对电泳速度的控制和作用于颗粒上的电泳力来开发一种亚微米颗粒的选择性分离技术。此外，提出了通过使用声辐射力和静电力的悬浮颗粒的连续分离技术，该技术考虑了粒子的大小差异，该技术实现了粒子的分离。较少的