Relation between allergic characteristics and intestinal flora

过敏特征与肠道菌群的关系

• 批准号: 18200044
• 负责人: NAKAJI Shigeyuki
• 金额: $ 20.22万
• 依托单位: Hirosaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18200044/
• 关键词: 腸内細菌; アレルギー; 疫学調査; 地域住民; 弘前市岩木地区; 健康・疾病パラメーター; 横断的研究; 糞便; 呼気ガス

A remarkable increase in the number of allergic disease has been observed in recent years. At the same time, the role of intestinal flora and its association with the disease has been gaining attention, although its etiology has not been clarified due to the difficulties to measure and culture intestinal flora. Approximately 1014 with more than 400 types of intestinal flora are present in a human body, and 60%-80% of them have been found to be unculturable. Consequently, previously reported researches have been carried out based on the 30% of culturable intestinal flora only. Therefore, it is extremely important to understand the overall image of intestinal flora in order to clarify the associations between allergy diseases and intestinal flora.The present study was targeted to residents at Iwaki area in Hirosaki city, Aomori prefecture in Japan to investigate the situations of allergy and intestinal flora. The association between them was analysed by using the multiple logistic regression analysis. Subjects were 747 Iwaki residents (281 males and 466 females) over 20 years old, and information on their allergic situations (presence of eczema, hay fever, alimentary allergy, respiratory allergy such as bronchial asthma, nose and eye allergy, and cutaneous allergy) as well as their intestinal flora were collected and measured (DNA profiling and ITU according to the Nagashima method). As a result, cutaneous allergy was found to be associated with some ITUs, and the significant associations were observed between nose and eye allergy and 9 ITUs which accounted for 41% of total ITUs.

近年来，过敏性疾病的数量显著增加。与此同时，肠道菌群的作用及其与疾病的关系也得到了越来越多的关注，尽管由于难以测量和培养肠道菌群，其病因尚未阐明。人体内存在大约1014种400多种肠道菌群，其中60%-80%被发现是不可培养的。因此，以前报道的研究仅基于30%的可培养肠道菌群。因此，了解肠道菌群的整体形象对于阐明变态反应性疾病与肠道菌群之间的关系是极其重要的。本研究以日本青森县广崎市磐城地区的居民为对象，调查过敏和肠道菌群情况。用多元Logistic回归分析两者之间的相关性。受试者为747名20岁以上的Iwaki居民(男性281人，女性466人)，收集并测量了他们的过敏情况(是否存在湿疹、花粉热、食物过敏、呼吸道过敏如支气管哮喘、鼻子和眼睛过敏以及皮肤过敏)以及他们的肠道菌群(DNA图谱和ITU按Nagashima方法)。结果发现，皮肤过敏与某些过敏症有关，其中鼻子和眼睛过敏与9例过敏症显著相关，占总过敏症的41%。

项目成果

食物繊維 : 基礎と応用(日本食物繊維学会監修/日本食物繊維学会編集委員会編集)

膳食纤维：基础与应用（日本膳食纤维学会监修/日本膳食纤维学会编辑委员会编）

• 发表时间: 2008
• 作者: 中路重之;他
• 通讯作者: 他

Association between sleep duration and hemoglobin A1c level

• DOI: 10.1016/j.sleep.2007.07.017
• 发表时间: 2008-10-01
• 期刊: SLEEP MEDICINE
• 影响因子: 4.8
• 作者: Nakajima, Hiromi;Kaneita, Yoshitaka;Ohida, Takashi
• 通讯作者: Ohida, Takashi

比較的低頻度の健康実践教室の参加が生活習慣、各種健康指標に及ぼす効果について『岩木健康増進プロジェクト』での試み

“磐城健康促进项目”研究了相对较少参加健康实践课程对生活习惯和各种健康指标的影响。

• 发表时间: 2009
• 作者: 高橋一平;梅田孝;檀上和真;松坂方士;井上亮;山居聖典;中路重之
• 通讯作者: 中路重之

Are individuals with lower neutrophil oxidative burst activity more prone to Helicobacter pylori infection?

中性粒细胞氧化爆发活性较低的个体是否更容易感染幽门螺杆菌？

• 发表时间: 2008
• 期刊: Luminescence 23(3)
• 作者: Matsuzaka M;Fukuda S;Yamai K;Tsuya R;Fukuoka Y;Takahashi I;Yaegaki M;Shimoyama T;Sakamoto J;Umeda T;Nakaji S.
• 通讯作者: Nakaji S.

The prevalence of irritable bowel syndrome among the Japanese general population.

日本普通人群中肠易激综合症的患病率。

• 发表时间: 2008
• 作者: Yamai K,. Umeda T;Inoue R;Tsuya R;Iwane K;Chisyaki T;Matsuzaka M;Takahashi I;Danjo K;Nakaji S.
• 通讯作者: Nakaji S.