Search for Bioactive Natural Products for Molecular Target Chemotherapy of Cancer

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To explore new lead compounds for molecular target chemotherapy of cancer, we have established screening systems based on the novel biological and molecular biological findings of cancer. Then, we have searched bioactive natural compounds from the extracts libraries of marine organisms, marine-derived microbe and medicinal plants by constructed bioassay-guided separation. As a result, we have found seven bioactive compounds totally and examined total synthesis, structure-activity relationship, and synthesis of model compounds. Moreover, the mechanistic-studies were performed by the chemical biology method.