Search for Bioactive Natural Products for Molecular Target Chemotherapy of Cancer

为了探索新的先导化合物用于癌症的分子靶向化疗，我们建立了基于癌症新的生物学和分子生物学发现的筛选系统。然后，我们通过构建生物测定导向的分离方法，从海洋生物、海洋微生物和药用植物的萃取库中寻找具有生物活性的天然化合物。因此，我们共发现了7个具有生物活性的化合物，并对模型化合物的全合成、构效关系和合成进行了考察。并用化学生物学方法对其作用机理进行了研究。

To explore new lead compounds for molecular target chemotherapy of cancer, we have established screening systems based on the novel biological and molecular biological findings of cancer. Then, we have searched bioactive natural compounds from the extracts libraries of marine organisms, marine-derived microbe and medicinal plants by constructed bioassay-guided separation. As a result, we have found seven bioactive compounds totally and examined total synthesis, structure-activity relationship, and synthesis of model compounds. Moreover, the mechanistic-studies were performed by the chemical biology method.