Establishment of in vivo screening system using Medaka fish toward to the drug discovery

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We succeeded in establishing the screening system using Medaka fish to search new medicinal leads that are effective to the animal models. Specifically, we established screening system for searching the bioactive natural products that is able to regulate the re-production of the tail and fins, which reflects the forming of blood and lymphatic vessels. In addition, we have re-discovered marine spongian alkaloid, manzamine A, from our extract library as an inhibitor of re-production of the tail and fins by using established bioassay-guided separation.