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Search for Indonesian Marine Life as Medicinal Resource

寻找印度尼西亚海洋生物作为药用资源

基本信息

批准号：
09041184
负责人：
KOBAYASHI Motomasa
金额：
$ 8.45万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09041184/
关键词：
Indonesia Marine invertebrate Marine resource Marine sponge Biological active

项目摘要

The sea will continue to play important roles for the future of the human being not only as the source of food and energy but also for the conservation of environment Other than these roles. the sea is also expected to provide biologically active substances, which have potential to be developed into new medicines. Owing to the deterioration of coastal environment caused by industrial and municipal effluents and also by sedimentation of red clay discharged from land development, existence of sessile marine organisms are endangered in the coasts of Japan. Similar situation is developing in Indonesia, especially along the coasts of Jakarta and other coastal cities. Considering these situations, it is important to initiate the study of Indonesian marine organisms as sources of lead compounds for new medicines before some of these species disappear from the coastal waters.The present research is carried out by the project in collaboration with Pusat Penelitian dan Pengembangan Oseanologi (R … More esearch and Development Center for Oceanology)-LIPI, Indonesia and Osaka University and University of the Ryukyus, Japan. The objectives of this proposal are to conduct a joint research on medicinal potential of Indonesian marine organisms and to promote scientific exchange between Indonesia and Japan in the disciplines encompassing marine biology, natural product chemisry, and biomedical science. The Indonesian waters' are known to be rich in diverse species of sessile organisms such as sponges and soft corals. However, their regional and biological distribution and biomedical potential arc scarcely understood. We, a group of scientists from both Indonesia and Japan, aim to conductj survey, collection, and chemical and pharmaceutical investigation of these organisms.The survey was proceeded at the coral reef of Spermonde Islands, Ujung Pandang, South Sulawesi, in August. 1997, and the coral reef of Lombok Island in August, 1998. Mainly sessile invertebrates such as sponges and tunicate were surveyed and collected by scuba diving. The extracts of collecting samples were subjected to the screening bioassays (e.g. antimicrobial activity, cytotoxic activity against cultured tumor cells (KB.LI210), reversal activity of multi-drug resistance in tumor cell (KV-C2, KB-CV6O, and KB-3-1 cell lines), and other biological activities. Less

海洋将继续为人类的未来发挥重要作用，不仅是作为食物和能源的来源，而且除了这些作用外，还将对保护环境发挥重要作用。海洋还有望提供生物活性物质，这些物质有可能被开发成新药。由于工业和城市污水造成的海岸环境恶化，以及土地开发排放的红粘土的沉积，日本海岸固着海洋生物的生存受到威胁。类似的情况在印度尼西亚也在发展，特别是在雅加达沿海和其他沿海城市。考虑到这些情况，重要的是在印尼海洋生物中的一些物种从沿海水域消失之前，启动这些海洋生物作为新药先导化合物来源的研究。本研究是由该项目与Pusat Penelitian Dan Pengembangan Oseanologi(R…)合作进行的更多海洋学研究和发展中心)-印度尼西亚LIPI和日本大阪大学和琉球大学。这项建议的目的是对印度尼西亚海洋生物的药用潜力进行联合研究，并促进印度尼西亚和日本在海洋生物学、天然产品化学和生物医学科学领域的科学交流。众所周知，印度尼西亚水域富含海绵和软珊瑚等多种固足生物。然而，它们的区域和生物分布以及生物医学潜力却鲜为人知。我们是一组来自印度尼西亚和日本的科学家，他们的目标是对这些生物进行调查、采集以及化学和药物调查。调查于8月在南苏拉威西省乌荣潘当的斯珀蒙德群岛珊瑚礁进行。1997年和1998年8月龙目岛的珊瑚礁。调查和采集的主要是固着的无脊椎动物，如海绵和被囊类。对采集的样品进行抗菌活性、对培养肿瘤细胞的细胞毒活性(KB.LI210)、肿瘤细胞多药耐药逆转活性(KV-C2、KB-CV60、KB-3-1细胞株)等生物活性筛选。较少