Elucidation of bisphenol A low-dose effects mediated through the nuclear receptor ERRγ

内分泌干扰物双酚A(BPA)的低剂量效应问题是目前尚未解决的巨大社会难题。在本研究中，我们阐明了几个受双酚A靶向雌激素相关受体γ(ERRγ)调控的转录因子，发现双酚A通过ERRγ抑制神经2a的神经元投射。我们还阐明了给果蝇注射双酚A会引起果蝇的多动障碍，从而对果蝇的昼夜节律产生不利影响。

The issue of low-dose effects of endocrine disruptor bisphenol A (BPA) is currently immense social difficulty unsolved. In the present study, we clarified several transcription factors regulated by BPA's target estrogen-related receptor gamma (ERRγ), and found that BPA inhibits the Neuro2a's neuron projection mediated through ERRγ. We also elucidated that BPA administration on the fruit fly Drosophila afford the adverse effects on their circadian rhythms by eliciting a hyperactivity disorder.