Triple-quadrupol mass spectrometer (LC-MS)

三重四极杆质谱仪 (LC-MS)

• 批准号: 451316294
• 金额: --
• 依托单位: Johannes Gutenberg-Universität Mainz
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2020
• 资助国家: 德国
• 起止时间: 2019-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/451316294?language=en
• 关键词: Triple; quadrupol; mass; spectrometer; LC

This application is for a replacement instrument for a much-used triple-quadrupole mass-spectrometer in an LC-MS (liquid chromatography/mass spectrometry) combination. Only the mass spectrometer is being applied for, since the chromatography compound is not yet in need of replacement. At the Institute of Pharmaceutical and Biomedical Sciences, LC-MS is being intensively conducted in a variety of perspectives, including structure elucidation, assay development, and quantification. The instrument is required foremost for quantification purposes in a number of research projects. The current instrument has made particularly significant contributions to the international reputation of the Helm group in the context of sensitive detection and quantification of modified RNA nucleosides, and, in order to uphold this reputation, a modern successor instrument is necessary. In addition to research in the field of RNA modifications, where cooperations are being implemented, among others, with colleagues in the own institute, the instrument will also be applied for drug research, for example for the detection and quantification of enzyme cofactors.

这一应用是为了取代LC-MS(液-质联用)中常用的三重四极杆质谱仪的仪器。只有质谱仪被应用，因为层析化合物还不需要更换。在药学和生物医学科学研究所，LC-MS正在不同的角度密集进行，包括结构阐明、分析开发和定量。在一些研究项目中，为了量化的目的，首先需要该仪器。目前的文书在灵敏地检测和量化修饰的核糖核酸方面对赫尔姆小组的国际声誉作出了特别重大的贡献，为了维护这一声誉，有必要制定一项现代的后续文书。除了在RNA修饰领域进行研究外，该仪器还将应用于药物研究，例如检测和量化酶辅助因子。