Triple-quadrupol mass spectrometer (LC-MS)

本申请是在LC-MS（液相色谱/质谱）组合中广泛使用的三重四极杆质谱仪的替代仪器。目前只使用质谱仪，因为色谱化合物还不需要更换。在制药和生物医学科学研究所，LC-MS正在从多种角度进行深入研究，包括结构阐明、分析开发和定量。在许多研究项目中，该仪器首先需要用于量化目的。目前的仪器在修饰RNA核苷的敏感检测和定量方面为Helm集团的国际声誉做出了特别重大的贡献，为了维护这一声誉，需要一种现代化的后续仪器。除了在RNA修饰领域的研究之外，该仪器还将应用于药物研究，例如用于酶辅助因子的检测和定量。

This application is for a replacement instrument for a much-used triple-quadrupole mass-spectrometer in an LC-MS (liquid chromatography/mass spectrometry) combination. Only the mass spectrometer is being applied for, since the chromatography compound is not yet in need of replacement. At the Institute of Pharmaceutical and Biomedical Sciences, LC-MS is being intensively conducted in a variety of perspectives, including structure elucidation, assay development, and quantification. The instrument is required foremost for quantification purposes in a number of research projects. The current instrument has made particularly significant contributions to the international reputation of the Helm group in the context of sensitive detection and quantification of modified RNA nucleosides, and, in order to uphold this reputation, a modern successor instrument is necessary. In addition to research in the field of RNA modifications, where cooperations are being implemented, among others, with colleagues in the own institute, the instrument will also be applied for drug research, for example for the detection and quantification of enzyme cofactors.