Triple-Quadrupol Mass spectrometer

三重四极杆质谱仪

• 批准号: 453027627
• 金额: --
• 依托单位: Rheinische Friedrich-Wilhelms-Universität Bonn
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2020
• 资助国家: 德国
• 起止时间: 2019-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/453027627?language=en
• 关键词: Triple; Quadrupol; Mass; spectrometer

The qualitative and quantitative analysis of chemical compounds is of central importance in drug research. The research-oriented Faculty of Pharmacy at the University of Bonn is broadly interconnected via the PharmaCenter Bonn, a Research Center for Innovative Drugs and Pharmacotherapy, and plays a central role in the area of life and health sciences. Hereby, we request a triple-quadrupol mass spectrometer for the platform „Chemical Analytics“ of the Faculty of Pharmacy for the sensitive quantitative analysis of small molecules. This MS instrument is urgently required for several, mostly third party-funded joint projects (e.g. GRK1873, FOR2372, FOR2625, FOR2685, SFB1328, TR-SFB259, TR-SFB261), since the currently available instruments are insufficient. A broad spectrum of analytical problems is to be handled, ranging from the quantitative determination of drug concentrations and metabolites in organoids and animal tissues, and the analysis of organic compounds in fossils, to innovative proteomics approaches. The platform for Chemical Analytics, which is associated with the Department of Pharmaceutical & Medicinal Chemistry, offers analytical service for the entire Faculty of Pharmacy, the PharmaCenter Bonn and beyond. The required mass spectrometer for quantitative analysis is complementary to the MS instruments that are available at the neighbouring, closely collaborating Chemical Institutes, which are focused on qualitative analysis and imaging.The new mass spectrometer will be utilized interdisciplinarily, between faculties and in the frame of (inter)national projects. Directly involved in the present application are besides the Department of Pharm. & Med. Chemistry (Müller, Gütschow), the Department of Pharmaceutical and Cell-Biological Chemistry (Hansen, Bendas), the Institute of Pharmaceutical Biology (König, Crüsemann), the Institute of Organic Chemistry (Menche, Engeser), and the Medical Faculty with the Institute of Molecular Biology and Biochemistry (Gieselmann, Winter) and the Institute of Pharmacology & Toxicology (Pfeifer). The envisaged user group, comprising high-ranking, experienced scientists as well as young talented scientists (Crüsemann, Engeser), will ensure complete occupancy of the instrument for work on sophisticated projects. Since students of Pharmacy are trained to become experts for Pharmaceutical Analytics including Instrumental Analytics, the MS instrument is also planned to be used for teaching (undergraduate research projects, and subsequent Master theses). Important criteria for the selection of the optimal system include (i) high sensitivity and linearity, (ii) flexibility, (iii) masses up to 2000 D, and (iv) determination of isomers.

化合物的定性和定量分析在药物研究中至关重要。波恩大学药学院以研究为导向，通过创新药物和药物治疗研究中心PharmaCenter Bonn广泛互连，并在生命和健康科学领域发挥核心作用。因此，我们请求为药学院的平台“化学分析”提供三重四极杆质谱仪，用于小分子的灵敏定量分析。由于目前可用的仪器不足，几个主要由第三方资助的联合项目（例如GRK 1873、FOR 2372、FOR 2625、FOR 2685、SFB 1328、TR-SFB 259、TR-SFB 261）迫切需要这种质谱仪。要处理的分析问题范围很广，从类器官和动物组织中药物浓度和代谢物的定量测定，到化石中有机化合物的分析，再到创新的蛋白质组学方法。化学分析平台与制药和药物化学系相关联，为整个药学院，波恩制药中心及其他地方提供分析服务。定量分析所需的质谱仪与邻近的密切合作的化学研究所提供的MS仪器相辅相成，后者专注于定性分析和成像。新的质谱仪将在院系之间和（国际）国家项目框架内跨学科使用。除了药学和医学化学系之外，直接参与本申请的还有（Müller，Gütschow），药物和细胞生物化学系（汉森，本达斯），药物生物学研究所（König，Crüsemann），有机化学研究所（Menche，Engeser）和医学系分子生物学和生物化学研究所（Gieselmann，Winter）和药理学和毒理学研究所（Pfeifer）。设想的用户组由资深的高级科学家和年轻的天才科学家（Crüsemann、Engeser）组成，将确保仪器完全用于复杂项目的工作。由于药学专业的学生经过培训成为药物分析专家，包括仪器分析，MS仪器也计划用于教学（本科研究项目和随后的硕士论文）。选择最佳系统的重要标准包括（i）高灵敏度和线性，（ii）灵活性，（iii）质量高达2000 D，和（iv）异构体的测定。