Regenerative response to insults : a novel strategy based on endothelial regeneration

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The objectives of this study were to evaluate the regenerative response of endothelium in patients with systemic inflammatory response syndrome and to examine the effects of mesenchymal stem cells in a rat model with multiple organ dysfunction syndrome (MODS). In patients with sepsis, long-term endothelial activation was observed with increased endothelial progenitor cells in blood and enhanced VEGF receptors on these cells. Transplantation of mesenchymal stem cells inhibit the production of inflammatory cytokines, protect against endothelial damage and improve survival in a rat model with MODS. Transplantation of mesenchymal stem cells may be a novel strategy to attenuate MODS.