Regenerative response to insults : a novel strategy based on endothelial regeneration

本研究的目的是评估全身炎症反应综合征患者的内皮再生反应，并检查间充质干细胞在多器官功能障碍综合征（MODS）大鼠模型中的作用。在脓毒症患者中，观察到长期内皮激活，血液中内皮祖细胞增加，这些细胞上的VEGF受体增强。间充质干细胞移植抑制炎症细胞因子的产生，保护内皮细胞免受损伤，并改善MODS大鼠模型的存活率。骨髓间充质干细胞移植可能是减轻MODS的新策略。

The objectives of this study were to evaluate the regenerative response of endothelium in patients with systemic inflammatory response syndrome and to examine the effects of mesenchymal stem cells in a rat model with multiple organ dysfunction syndrome (MODS). In patients with sepsis, long-term endothelial activation was observed with increased endothelial progenitor cells in blood and enhanced VEGF receptors on these cells. Transplantation of mesenchymal stem cells inhibit the production of inflammatory cytokines, protect against endothelial damage and improve survival in a rat model with MODS. Transplantation of mesenchymal stem cells may be a novel strategy to attenuate MODS.