A novel strategy for heat stroke: Transplantation of mesenchymal stem cells

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The objectives of this study were to evaluate the pathophysiology and regenerative response of endothelium after heat stroke and to examine the effects of mesenchymal stem cells in a rat model. The serum concentrations of tumor necrosis factor alpha (TNF-α), interleukin-6, soluble thrombomodulin, and soluble endothelial selectin significantly increased at 3 and 6 hours after heat stroke. In the lung, interstitial edema, structural disruption of the alveolar lumen, and intra-alveolar hemorrhage were observed at 6 hours after heat stroke. Transplantation of mesenchymal stem cells was conducted to evaluate the effects to inhibit the production of inflammatory cytokines, protect against endothelial damage and improve survival in a rat model with heat stress.