Creation of Cementum Inducing peptide for functional Implant

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The purpose of this study was to create the cementum inducing peptide for functional implant which have a cementum with sharpy's fibers just same manner as natural tooth. We produced the artificial protein with Titanium-binding protein (TBP-1) which bind to the titanium, and RGD motif which connected to the integrin of the cells using Molclaft. We published these in vitro results on the Biomacromolecules (2008). From these results suggest that we could bind the various kinds of protein on the titanium surface on the titanium surface by TBP-1. In the near future, we could make a functional implant which have a periodontal ligament-like structure. In the mean time, Zirconium have given attention to implant materials instead of titanium, we investigate Zirconium binding protein as well as TBP.