Creation of Cementum Inducing peptide for functional Implant

本研究的目的是研制一种功能种植体的牙骨质诱导肽，其牙骨质中含有与天然牙完全相同的夏皮氏纤维。我们制备了钛结合蛋白(TBP-1)和RGD基序的人工蛋白，TBP-1与钛结合，RGD基序与细胞整合素连接。我们在《生物大分子》(2008)上发表了这些体外实验结果。这些结果表明，TBP-1可以将钛表面的各种蛋白质结合到钛表面。在不久的将来，我们可以制造出具有牙周韧带样结构的功能性种植体。同时，随着钛在植入材料上的应用越来越受到重视，我们对锆结合蛋白和钛结合蛋白进行了研究。

The purpose of this study was to create the cementum inducing peptide for functional implant which have a cementum with sharpy's fibers just same manner as natural tooth. We produced the artificial protein with Titanium-binding protein (TBP-1) which bind to the titanium, and RGD motif which connected to the integrin of the cells using Molclaft. We published these in vitro results on the Biomacromolecules (2008). From these results suggest that we could bind the various kinds of protein on the titanium surface on the titanium surface by TBP-1. In the near future, we could make a functional implant which have a periodontal ligament-like structure. In the mean time, Zirconium have given attention to implant materials instead of titanium, we investigate Zirconium binding protein as well as TBP.