A study to develop homeostatic biomaterial

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1 : A Study of implant-tissue interfaceThe peri-implant epithelium may have less hemidesmosomal attachment and maintain lower capacity to act as a proliferative defense mechanism than does the junctional epithelium. Cervicular fluid flow may help the low proliferative activity of the peri-implant epithelium.With some implant types, an understanding of how early granulation and bone healing occurs following placement of the implant, and how healing can be influenced by the distance from the implant surface to core implant, is crucial to optimizing implant surface geometry.Ultrastructurally, bone-titanium interface there are poorly mineralized layr consisting of delicate fibril-like structures or the slender cell layr through a thin amorphous zone (20-40nm). This amorphous zone was positive for uthenium red which has a high affinity for proteoglycans and this may be an essential for attachment between the slender cell layr poorly mineralized layr or mature bone and titanium.2 : Develop homeostatic biomaterialIt is suggested that, after 4-META penetration into the pulp, most of the penetrated 4-META forms STHL at the surface area of pulp, and the residue penetrates deep into pulp tissue to form and immature polymer. The remaining unpolymerized MMA monomer, 4 META monomer, butanol, and boric acid reach the front edge of penetration. These phenomena might cause decrease of blood flow and may disturb the early stage of pulpal healing when 4-META is applied on the pulp.From now on we will try to produce new material which produce much more thicker soft tissue hybrid layr.