Nucleic acid-based nanomachine systems for tumor treatment

点击翻译按钮获取中文摘要

In this research project, we studied polymer materials to construct therapeutic nanomachine systems for tumor treatment. Polymer materials that accumulates in tumor tissues and exhibits nucleic acid chaperoning activity were designed and evaluated. Cationic comb-type copolymers having hydrophilic graft chains were found to accumulate effectively in tumor tissue subcutaneously implanted in mice. The copolymer was also found to facilitate structural transition between stem-loop structure and duplex and assembly of quadruplex DNA. These results suggested that activity of functional nucleic acids could be regulated with the cationic copolymers at tumor sites.