Three dimensional design of nanostructures for label-free biosensing

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The purpose of this study is development of a new biosensing technology based on the combination of silicon nanotechnology and design of bio-interfaces. We have examined formation of artificial bilayer lipid membranes (BLMs)in microfabricated apertures and nanoporous structures. We succeeded in preparation of free-standing BLMs having dramatically improved membrane stability. Such stable BLMs will open up variety of applications. In addition, we have examined efficient formation of nano structures as a new platform for nano-bioelectronics. Our approaches are useful for innovation of novel nano-recognition interfaces and bioelectronics based on the design of nanostructure interfaces.