Evaluation and dynamic measurement of biomembrane transporter using on-chip tethered microtool

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We promoted the research on basic technologies for on-chip single cell analysis to measure the cell variations induced by control of the environmental conditions and physical stimulus using functional microtool. We fabricated the microfluidic chip having local cell cage by micro-processing based on photofabrication. Functional microtools such as tethered shape tool, flexible tool and sensing tool, were also fabricated. We succeeded in quantitative evaluation of biomembrane transporter by measuring the volume variation of the cell induced by osmotic stimulus on this system.