STRUCTURAL BIOLOGY ON MATURATION PROCESS OF METALLOPROTEINS

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Six Hyp proteins(HypA, B, C, D, E, and F) are primarily involved in the maturation process of[NiFe] hydrogenases which catalyze reversible hydrogen production and consumption. These proteins incorporate a complex Ni/Fe cluster into a protein subunit of[NiFe] hydrogenases. On the basis of our success in the first structure determination of HypC, HypD, and HypE, we have carried out here structure an alyses of HypA, HypB, and HypF and of complexes between HypC, HypD, and HypE to obtain mechanistic insights into the[NiFe] hydrogenase maturation.