Regulation of transcription factors and neuronal development by necdin-Sirt1 complex
Regulation of transcription factors and neuronal development by necdin-Sirt1 complex
批准号:
21890123
负责人:
HASEGAWA Koichi
金额:
$1.53万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Research Activity Start-up
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
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英文摘要
Necdin is a positive regulator of Sirt1 protein deacetylase. In this study, I focused Foxo1 that is related for feeding. Necdin-Sirt1 complex deacetylased Foxo1 and modified thermoregulation through controlling neuropeptides and thyroid hormones.
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Neural stem cell proliferation is regulated through interaction between necdin and Bmi1 polycomb complex protein(神経幹細胞の増殖はnecdinとポリコーム複合体タンパク質Bmi1の相互作用によって制御されている)
necdin 和 Bmi1 多梳复合蛋白之间的相互作用调节神经干细胞增殖
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[南出良平, 長谷川孝一, 大雲剛志, 吉川和明]
通讯作者:
吉川和明
Acetylation status of transcription factors is regulated by neuronal necdin-Sirt1 complex(ニューロンにおけるnecdin-Sirt1複合体による転写因子アセチル化状態の制御)
转录因子的乙酰化状态受神经元 necdin-Sirt1 复合物调节(神经元中 necdin-Sirt1 复合物控制转录因子乙酰化状态)
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[中西勇太, 中原徹, 鈴木慎太郎, 田中智博, 大橋南美, 堤浩, 鳴海哲夫, 野村渉, 駒野淳, 山本直樹, 玉村啓和, 長谷川孝一]
通讯作者:
長谷川孝一
Necdin regulates neural stem cell proliferation during postnatal development
Necdin 调节出生后发育过程中的神经干细胞增殖
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Yamagata Y, et al., 金子雅幸, 橋長秀典]
通讯作者:
橋長秀典
Epigenetic regulation of necdin gene expression during neural development(神経分化におけるnecdin遺伝子のエピジェティックな発現制御)
神经发育过程中necdin基因表达的表观遗传调控
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[大雲剛志, 長谷川孝一, 藤原一志郎, 吉川和明]
通讯作者:
吉川和明
Necdin enhances Sirt1-dependent deacetylation of Foxo1 to control hypothalamic thermoregulation
Necdin 增强 Foxo1 的 Sirt1 依赖性脱乙酰化以控制下丘脑温度调节
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[長谷川孝一, 吉川和明]
通讯作者:
吉川和明
共 21 条
Genome and genetic analysis of the interactions between host (Pine tree), pathogen (pine wood nematode), and bacteria: focused on the oxidative stress responses
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批准号:26450204
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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财政年份:2014
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Comparing Climate Change Policy Networks Project
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批准号:19402033
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项目类别:Grant-in-Aid for Scientific Research (B)
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依托单位:
Climate Change Protection Policy and Collaborative Processes in Local Community
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负责人:HASEGAWA Koichi
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依托单位:
A Study of Social Conflicts on Japanese Energy Policy and Nuclear Facilities
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批准号:04301013
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项目类别:Grant-in-Aid for Co-operative Research (A)
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负责人:HASEGAWA Koichi
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依托单位:
海外基金