Correlation between the expression patterns of cytokeratins/cell differentiations and the clinico-patholigical findings in oral squamous cell carcinoma

口腔鳞状细胞癌细胞角蛋白/细胞分化的表达模式与临床病理结果的相关性

• 批准号: 21890186
• 负责人: TOYOSHIMA Takeshi
• 金额: $ 1.5万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21890186/
• 关键词: 口腔扁平上皮癌; サイトケラチン; 分化度; Δp63; Gli2; 免疫組織化学的染色; real-time PCR法; 分化; 原発巣; 末梢血

The expression patterns of 6 kinds of CK were examined immunohistochemically in the 105 biopsy specimens of primary site from OSCC patients. The results reveal that CK 17 was significantly expressed in compared to those of other CKs (CK14、CK16、CK18、CK19、CK20). Moreover, a correlation with the clinicopatholigical findings and the Δ p63 pattern were examined immunohistochemically. CK17 was significantly expressed in the high frequency in the center of tumor (P<0.05), whileΔp63 was significantly expressed in the high frequency in the outer layer of tumor (P<0.05). The expression patterns of CK17 and Gli2 were examined immunohistochemically in the 13 biopsy specimens of primary site from OSCC patients. CK17 and Gli2 were co-expressed frequently in the center of tumor, whileGli2 was expressed in the outer layer of tumor.

应用免疫组化方法检测了105例口腔鳞癌原发灶组织中6种CK的表达。结果表明，CK17在正常人子宫内膜组织中的表达明显高于其它几种CK（CK14、CK16、CK18、CK19、CK20）。此外，与临床病理结果和Δ p63模式的相关性进行了化学检测。CK17在肿瘤中心高频率表达（P<0.05），Δp63在肿瘤外层高频率表达（P<0.05）。应用免疫组化方法检测13例口腔鳞癌原发灶组织中CK17和Gli2的表达。CK17和Gli2在肿瘤中心常同时表达，而Gli2在肿瘤外层表达。

项目成果

口腔扁平上皮癌におけるサイトケラチン17の免疫組織化学的検討

细胞角蛋白17在口腔鳞状细胞癌中的免疫组织化学研究

• 发表时间: 2011
• 作者: 北村亮二

Immunohistochemical analysis of cytokeratin 17 in oral squamous cell carcinoma

口腔鳞状细胞癌中细胞角蛋白17的免疫组织化学分析

• 发表时间: 2010
• 作者: R KITAMURA;T TOYOSHIMA;S KAWANO;T KIYOSUE;R MATSUBARA;Y GOTO;K OOBU;S NAKAMURA
• 通讯作者: S NAKAMURA

口腔扁平上皮癌におけるサイトケラチン17の発現についての検討

细胞角蛋白17在口腔鳞癌中表达的研究

• 发表时间: 2010
• 作者: 北村亮二;北村亮二・豊嶋健史・川野真太郎・清末崇裕・松原良太・後藤雄一・中村誠司
• 通讯作者: 北村亮二・豊嶋健史・川野真太郎・清末崇裕・松原良太・後藤雄一・中村誠司