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Would Cytokeratin be a new prognostic marker of oral squamous cell carcinoma?

Would Cytokeratin be a new prognostic marker of oral squamous cell carcinoma?
细胞角蛋白会成为口腔鳞状细胞癌的新预后标志物吗?
批准号:
23792356
负责人:
TOYOSHIMA Takeshi
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013

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中文摘要
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英文摘要
The aim of this study was to verify an correlation between CK positive cells and differentiation of oral squamous cell carcinoma (OSCC) in order to clarify if CK in tumor cell would be a new prognostic marker in patients with OSCC. In 20 patients, blood samples were taken pre/postoperatively and in follow-up periods for this study. The positive cases were 20/20 for CK17, 15/20 for CK19, and 12/20 for CK20. The chronological relative ratios were 1:0.73:0.87 for CK17, 1:1.14:1.36 for CK19, and 1:1.7:1.80 for CK20. Between rich and poor prognostic cases, the relative ratios of postoperative 1 month were 0.69 vs 1.38 for CK17, 1.02 vs 1.82 for CK19, and 5.48 vs 0.09 for CK20. These results indicate that CK17 might be a new prognostic marker of OSCC.
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In vitro induction of specific CD8(+) T lymphocytes by tumorassociated antigenic peptides in patients with oral squamous cell carcinoma
肿瘤相关抗原肽体外诱导口腔鳞状细胞癌患者特异性CD8( ) T淋巴细胞
DOI: 10.1016/j.canlet.2012.02.016
发表时间: 2012
期刊: Cancer Lett
影响因子: 9.7
作者: [Toyoshima, T., Kumamaru, W., Hayashida, J.-N., Moriyama, M., Kitamura, R., Tanaka, H., Yamada, A., Itoh, K., and Nakamura, S.]
通讯作者: S.
DOI: 10.1007/s00432-012-1202-6
发表时间: 2012-08
期刊: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
影响因子: 3.6
作者: [Kitamura, Ryoji, Toyoshima, Takeshi, Tanaka, Hideaki, Kawano, Shintaro, Kiyosue, Takahiro, Matsubara, Ryota, Goto, Yuichi, Hirano, Mitsuhiro, Oobu, Kazunari, Nakamura, Seiji]
通讯作者: Nakamura, Seiji
Apoptotic function of tumor-associated antigen
肿瘤相关抗原的凋亡功能
DOI: --
发表时间: 2014
期刊: RCAS1 in oral squamous cell carcinoma Journal of Translational Medicine
影响因子: --
作者: [Hideaki Tanaka, Takeshi Toyoshima, Kenzo Sonoda, Ryoji Kitamura, Masaaki Sasaguri, Shintaro Kawano, Ryota Matsubara, Yuichi Goto, Seiji Nakamura]
通讯作者: Seiji Nakamura
口腔扁平上皮癌由来細胞株における腫瘍関連抗原RCAS1(receptor-binding caner antigen expressed on SiSo cells)の発現と機能についての検討
口腔鳞癌来源细胞系中肿瘤相关抗原RCAS1(SiSo细胞上表达的受体结合癌抗原)的表达和功能研究
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [松原良太, 川野真太郎, 梯裕恵, 中村誠司, ほか, 1.田中秀明,豊嶋健史,園田顕三,北村亮二,川野真太郎,平野充広,神野哲平,中村誠司]
通讯作者: 1.田中秀明,豊嶋健史,園田顕三,北村亮二,川野真太郎,平野充広,神野哲平,中村誠司
Correlation between the expression patterns of cytokeratins/cell differentiations and the clinico-patholigical findings in oral squamous cell carcinoma
  • 批准号:
    21890186
  • 项目类别:
    Grant-in-Aid for Research Activity Start-up
  • 资助金额:
    $1.5万
  • 财政年份:
    2009
  • 负责人:
    TOYOSHIMA Takeshi
  • 依托单位:
海外基金