Would Cytokeratin be a new prognostic marker of oral squamous cell carcinoma?

细胞角蛋白会成为口腔鳞状细胞癌的新预后标志物吗？

• 批准号: 23792356
• 负责人: TOYOSHIMA Takeshi
• 金额: $ 2.75万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23792356/
• 关键词: 口腔扁平上皮癌; サイトケラチン; 分化度; 扁平上皮癌; 原発巣; 血中; 白板症

The aim of this study was to verify an correlation between CK positive cells and differentiation of oral squamous cell carcinoma (OSCC) in order to clarify if CK in tumor cell would be a new prognostic marker in patients with OSCC. In 20 patients, blood samples were taken pre/postoperatively and in follow-up periods for this study. The positive cases were 20/20 for CK17, 15/20 for CK19, and 12/20 for CK20. The chronological relative ratios were 1:0.73:0.87 for CK17, 1:1.14:1.36 for CK19, and 1:1.7:1.80 for CK20. Between rich and poor prognostic cases, the relative ratios of postoperative 1 month were 0.69 vs 1.38 for CK17, 1.02 vs 1.82 for CK19, and 5.48 vs 0.09 for CK20. These results indicate that CK17 might be a new prognostic marker of OSCC.

本研究的目的是验证CK阳性细胞与口腔鳞状细胞癌(OSCC)分化程度的相关性，以明确肿瘤细胞中的CK是否可作为口腔鳞癌患者预后的新指标。在这项研究中，20名患者在手术前/术后和随访期内采集了血样。CK17、CK19、CK20阳性病例分别为20/20、15/20、12/20。CK17、CK19和CK20的时间相对比例分别为1：0.73：0.87、1：1.14：1.36和1：1.7：1.80。预后好与差的病例术后1个月相对比值分别为：CK17为0.69比1.38，CK19为1.02比1.82，CK20为5.48比0.09。提示CK17可能是口腔鳞癌的一个新的预后指标。

项目成果

In vitro induction of specific CD8(+) T lymphocytes by tumorassociated antigenic peptides in patients with oral squamous cell carcinoma

肿瘤相关抗原肽体外诱导口腔鳞状细胞癌患者特异性CD8( ) T淋巴细胞

• DOI: 10.1016/j.canlet.2012.02.016
• 发表时间: 2012
• 期刊: Cancer Lett
• 影响因子: 9.7
• 作者: Toyoshima;T.;Kumamaru;W.;Hayashida;J.-N.;Moriyama;M.;Kitamura;R.;Tanaka;H.;Yamada;A.;Itoh;K.;and Nakamura;S.
• 通讯作者: S.

Association of cytokeratin 17 expression with differentiation in oral squamous cell carcinoma.

• DOI: 10.1007/s00432-012-1202-6
• 发表时间: 2012-08
• 期刊: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
• 影响因子: 3.6
• 作者: Kitamura, Ryoji;Toyoshima, Takeshi;Tanaka, Hideaki;Kawano, Shintaro;Kiyosue, Takahiro;Matsubara, Ryota;Goto, Yuichi;Hirano, Mitsuhiro;Oobu, Kazunari;Nakamura, Seiji
• 通讯作者: Nakamura, Seiji

Apoptotic function of tumor-associated antigen

肿瘤相关抗原的凋亡功能

• 发表时间: 2014
• 期刊: RCAS1 in oral squamous cell carcinoma Journal of Translational Medicine
• 作者: Hideaki Tanaka;Takeshi Toyoshima;Kenzo Sonoda;Ryoji Kitamura;Masaaki Sasaguri;Shintaro Kawano;Ryota Matsubara;Yuichi Goto;Seiji Nakamura
• 通讯作者: Seiji Nakamura

口腔扁平上皮癌由来細胞株における腫瘍関連抗原RCAS1(receptor-binding caner antigen expressed on SiSo cells)の発現と機能についての検討

口腔鳞癌来源细胞系中肿瘤相关抗原RCAS1（SiSo细胞上表达的受体结合癌抗原）的表达和功能研究

• 发表时间: 2013
• 作者: 松原良太;川野真太郎;梯裕恵;中村誠司;ほか;1.田中秀明，豊嶋健史，園田顕三，北村亮二，川野真太郎，平野充広，神野哲平，中村誠司
• 通讯作者: 1.田中秀明，豊嶋健史，園田顕三，北村亮二，川野真太郎，平野充広，神野哲平，中村誠司