Functional analysis of cancer-specific human T cells in NOG mice : Cell interaction of CD4, CD8 cells

点击翻译按钮获取中文摘要

Adoptive cell therapy(ACT) for cancer, in which T cells are collected from patient's peripheral blood, modified by the transduction of tumor-antigen specific T cell receptor(TCR) and re-administered to the same patient, is increasingly the subject of clinical trials. In this study, we aimed to establish a mouse model to analyze "in vivo" functions of the transferred T cells by utilizing immunocompromised(NOG) mice. We observed the regression of transplanted human esophageal tumor(HLA-A2402+, MAGE-A4+) growth only when T cells modified to express TCR, recognizing MAGE-A4(p143-151) peptide in the context of HLA-A2402, were co-administered. This model will provide us more detailed information about mechanism of efficacies of transferred T cells.