The functional roles of the Chromosome Passenger Complex influence the occurrence and progress of cancer.

染色体过客复合物的功能作用影响癌症的发生和进展。

• 批准号: 22890121
• 负责人: QI Guangying
• 金额: $ 1万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22890121/
• 关键词: Survivin; Aurora-B; INCENP; Borealin

The overexpression of Survivin Aurora-B, Borealin, and INCENP of the Chromosome Passenger Complex (CPC) has been reported in various cancers, but their relativity and roles are still unclearclar. In the present study, the interaction and functional correlation of the CPC protein in the progress of the cancer are examined. In oral squamous cell cancer (OSCC) cases, high expression of nuclear of Survivin, Aurora-B, and Borealin are well correlated with malignant behaviors. In Hela cells, it is showed that the 96 and 98^<th> amino acid are important for localization at the centromere and midbody and binding with Aurora-B, INCENP and Borealin.

在各种癌症中，已经报道了染色体乘客复合物（CPC）的Survivin Aurora-B，Borealin和Incenp的过表达，但它们的相对性和作用仍然没有吸引人。在本研究中，检查了CPC蛋白在癌症进展中的相互作用和功能相关性。在口腔鳞状细胞癌（OSCC）病例中，源性核，Aurora-B和Borealin的核表达高与恶性行为相关。在HeLa细胞中，表明96和98^<th氨基酸对于在Centromere和Middody的定位以及与Aurora-B，Incenp和Borealin结合至关重要。