High Resolution Chromatography Coupled Massspectrometer for Biomarker Discovery

用于生物标志物发现的高分辨率色谱耦合质谱仪

• 批准号: 453504869
• 金额: --
• 依托单位: Ludwig-Maximilians-Universität München (LMU)
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2021
• 资助国家: 德国
• 起止时间: 2020-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/453504869?language=en
• 关键词: Resolution; Chromatography; Coupled; Massspectrometer; Biomarker

The increasing interest of clinical research groups in proteomic investigations at the Core facility for protein Analysis of the LMU (Zentrallabor für Proteinanalytik, ZfP) led to the establishment of ZfP for clinical proteomics (ClinZfP). The high demand for measurements requested from clinical research groups can no longer be met with the available instruments. For this reason, two systems for the detection (EXPLORE) and validation (CONFIRM) of clinical biomarkers are requested in this and the related application.This increasing interest in clinical proteomics is also illustrated by the ZfP's membership in the recently established network of proteome laboratories in Munich (CLINSPECT-M), which is intended to meet the medical need for mass spectrometry in neurological diseases. CLINSPECT-M is one of four clusters funded by the Federal Ministry of Knowledge and Research (BMBF) in Germany to establish mass spectrometric methods in routine clinical applications (https://www.gesundheitsforschung-bmbf.de/de/clinspect- m-clinical-mass-spectrometry-center-munchen-10979.php). The increased measuring capacity that would become available by the acquisition of two mass spectrometers applied for, would allow the ClinZFP at the BMC to use the pipelines set up in CLINSPECT-M for other clinical questions and thus significantly improve proteomic research for clinical diagnostics and therapy

临床研究小组对LMU蛋白质分析核心设施（Zentrallabor für Proteinanalytik，ZfP）的蛋白质组学研究的兴趣日益增加，导致了临床蛋白质组学ZfP（ClinZfP）的建立。现有的仪器已无法满足临床研究小组对测量的高需求。由于这个原因，两个系统的检测（EXPLORE）和验证（CONFIRM）的临床生物标志物的要求，在这个和相关的应用。这在临床蛋白质组学的兴趣日益增加也说明了ZfP的成员在最近成立的网络蛋白质组实验室在慕尼黑（SPECT-M），这是为了满足医学需要的质谱在神经系统疾病。SPECT-M是由德国联邦知识与研究部（BMBF）资助的四个集群之一，用于在常规临床应用中建立质谱方法（https：www.gesundheitsforschung-bmbf.de/de/clinspect- m-clinical-mass-spectrometry-center-munchen-10979.php）。通过购买两台申请的质谱仪，可以增加测量能力，这将使BMC的ClinZFP能够使用在CSPECT-M中建立的管道来解决其他临床问题，从而显着改善临床诊断和治疗的蛋白质组学研究