The functional significance of the olivo-cerebellar input in obstacle avoidance during locomotion.

橄榄小脑输入在运动过程中避障的功能意义。

• 批准号: 24800018
• 负责人: SATO Yamato
• 金额: $ 1.58万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-08-31 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24800018/
• 关键词: 下オリーブ核－登上線維系; 障害物回避; 小脳; ラット; 筋電図; 下オリーブ核-登上線維系; 運動制御

The purpose of this study was to investigate the effect of lesions to the olivo-cerebellar pathway on obstacle avoidance during locomotion. The results are as follows. 1) The post-lesion animals showed excessive toe elevation, shortening stride length and hyper flexion of knee and ankle joints during the swing phase. 2) In post-lesion animals at normal ground locomotion, the vastus lateralis did not show muscle activity during the late swing phase. The biceps femoris showed muscle activity at lift-off. Moreover, the gastrocnemius showed prolongation of quiescent and active period during the stance phase and late swing phase, respectively. 3) In obstacle avoidance during locomotion, the post-lesion animals showed fluctuating toe trajectory. In this case, some muscle (the vastus lateralis, the biceps femoris, the tibialis anterior and the gastrocnemius) of avoiding limb showed different activity from pre-lesion animals.

本研究旨在探讨橄榄-小脑通路损伤对运动避障的影响。结果如下。1)损伤后的动物在摆动阶段表现出脚趾过度抬高、步幅缩短以及膝关节和踝关节过度屈曲。2)在损伤后的动物在正常的地面运动，股外侧肌没有显示在后期摆动阶段的肌肉活动。在离地时，股二头肌显示出肌肉活动。此外，腓肠肌的静止期和活动期分别在站立期和摆动后期延长。3)在避障运动中，损伤后的动物表现出波动的脚趾轨迹。在这种情况下，回避肢体的一些肌肉（股外侧肌、股二头肌、胫骨前肌和腓肠肌）显示出与损伤前动物不同的活动。

项目成果

平面歩行における下オリーブ核ー登上線維系破壊の影響

下橄榄核攀爬纤维系统破坏对平板行走的影响

• 发表时间: 2013
• 作者: 佐藤和;青木祥;柳原大
• 通讯作者: 柳原大

Lesion in the lateral cerebellum specifically produces overshooting of the toe trajectory in leading forelimb during obstacle avoidance in the rat

• DOI: 10.1152/jn.01048.2012
• 发表时间: 2013-10-01
• 期刊: JOURNAL OF NEUROPHYSIOLOGY
• 影响因子: 2.5
• 作者: Aoki, Sho;Sato, Yamato;Yanagihara, Dai
• 通讯作者: Yanagihara, Dai

ラットの平面歩行運動における小脳皮質中間部の薬理学的不活化の影響

小脑皮质中间部分的药理失活对大鼠平面运动的影响

• 发表时间: 2013
• 作者: 青木祥;佐藤和;柳原大
• 通讯作者: 柳原大

平面歩行における下オリーブ核―登上線維系破壊の影響―

平坦行走中的下橄榄核 - 攀爬纤维系统破坏的影响 -

• 发表时间: 2013
• 作者: 佐藤和;青木祥;柳原大
• 通讯作者: 柳原大