The effect of the exposure to continuous compressive force on disc cells in the temporomandibular joint- focusing on the intermediate filaments.

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Ultrastructue of the desmin immunopositive disc cell following exposure to continuous compressive force was examined under electron microscope. Desmin-positive cells possessed comparatively large nucleus and sparse organelle in thier cytoplasm, which means poorly-differentiated type. The articular disc cells showing desmin-immunoreactivity possessed cytoplasmic processes which had also immunoreaction of desmin. This morphological feature indicated that desmin positive cells have moving and migration ability. In addition, around the desmin positive cells, some small blood vessels were observed.Immunohistochemical observation showed that a lot of articular disc cells were immunestained with VEGF (vascular endothelial growth factor) and some cells facing the articular cavity showed RECA-1 which is the antibody specific to vascular endothelium.In conclusion, there is a possibility that the formation of new vessels commenced in response to the extraordinary compressive force.