Elucidation of of non-alcoholic steatohepatitis exacerbation mechanism by dental infection and effects of dental treatment

阐明牙科感染引起的非酒精性脂肪性肝炎恶化机制及牙科治疗效果

• 批准号: 24890138
• 负责人: FURUSHO Hisako
• 金额: $ 1.91万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-08-31 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24890138/
• 关键词: P.gingivalis; 歯性感染; NASH; 免疫; 歯科処置; LPS; E.coli; パルミチン酸; 肝構成細胞; 炎症性サイトカイン

Effect of Porphyromonas gingivalis (P.g.) on non-alcoholic steatohepatitis (NASH) were examined. Various bacterial components (lipopolysaccharaide;LPS, flagellin and DNA) activate natural immune pathways through TLR2, 4, 5 and 9, resulting in upregulation of inflammatory cytokine expression and inflammasome activation . In fatty liver, showing upreglation TLR2 expression, the increased sensitivity of P.g.-LPS, which is TLR2 ligand, may cause stronger pathogenesis. Moreover, elimination of P.g.-odontogenic infection in P.g.-infected / high fat diet induced NASH mouse model reduced inflammatory cytokines expression and inflammatory cytokines expression and inflammatory cytokines expression and inflammation in liver. It indicates that dental therapy may have beneficial impact on management of NASH.

牙龈卟啉单胞菌（P.g.）对非酒精性脂肪性肝炎（NASH）进行了检查。各种细菌组分（脂多糖;LPS、鞭毛蛋白和DNA）通过TLR 2、4、5和9激活天然免疫途径，导致炎性细胞因子表达和炎性体激活的上调。在脂肪肝中，显示上调TLR 2表达，P.g.- LPS作为TLR 2的配体可能具有更强的致病作用。此外，消除P.g.- P.g.牙源性感染感染/高脂肪饮食诱导的NASH小鼠模型降低了肝脏中的炎性细胞因子表达和炎性细胞因子表达以及炎性细胞因子表达和炎症。这表明牙科治疗可能对NASH的管理产生有益的影响。

项目成果

Effect of Porphyromonas gingivalis on the progression non-alcoholic steatohepatitis

牙龈卟啉单胞菌对非酒精性脂肪性肝炎进展的影响

• 发表时间: 2013
• 作者: 椋本成俊;吉田賢史;赤坂浩亮;江島泰生;宮脇大輔;上薗 玄;佐々木良平;大月直樹;丹生健 一;FurushoH,Miyauchi M,Ao M,Inubushi T,Takata T
• 通讯作者: FurushoH,Miyauchi M,Ao M,Inubushi T,Takata T

Effect of Porphyromonas gingivalis on the progression non-alcoholic steatohepatitis.

牙龈卟啉单胞菌对非酒精性脂肪性肝炎进展的影响。

• 发表时间: 2013
• 作者: 椋本成俊;吉田賢史;赤坂浩亮;江島泰生;宮脇大輔;上薗 玄;佐々木良平;大月直樹;丹生健 一;FurushoH,Miyauchi M,Ao M,Inubushi T,Takata T;国定俊之;曽我賢彦;椋本成俊 宮脇大輔 赤坂浩亮 王天縁 清 水康之 上薗玄 吉田賢史 江島泰生 佐々木良平 吉田直碁 表田真弓 西谷隆治 南利明 青山裕一;Hisako Furusho
• 通讯作者: Hisako Furusho

Dental infection of Porphyromonas gingivalis exacerbates high fat diet-induced steatohepatitis in mice

• DOI: 10.1007/s00535-012-0738-1
• 发表时间: 2013-11-01
• 期刊: JOURNAL OF GASTROENTEROLOGY
• 影响因子: 6.3
• 作者: Furusho, Hisako;Miyauchi, Mutsumi;Takata, Takashi
• 通讯作者: Takata, Takashi