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High-resolution imaging and tissue characterization using a miniaturized ultrasound probe mounted on a puncturing needle

使用安装在穿刺针上的小型超声探头进行高分辨率成像和组织表征

基本信息

批准号：
10480239
负责人：
KUDO Nobuki
金额：
$ 6.72万
依托单位：
HOKKAIDO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B).
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2000
项目状态：
已结题

项目摘要

In this study, a high-frequency miniaturized ultrasound probe mounted on a puncturing needle and an imaging system for this probe have been developed. The usefulness of this imaging system has been evaluated in in vitro and in vivo experiments. We have also studied the feasibility of tissue characterization using ultrasound attenuation in a high-frequency region. The following results were obtained.Development of the miniaturized ultrasound probe and imaging system A miniaturized probe mounted on a 16-20 gage puncturing needle that can be stuck into a tissue has been developed. A 2-D ultrasound image was obtained by the developed imaging system within about 6 seconds. Practical usefulness of this system was examined by phantom and animal experiments.Detection of blood flow in a small vessel using a correlation technique The imaging system was applied to the detection of blood flow using a correlation technique in a small vessel at deep portion of a body. To evaluate this flow detection method, we carried out in vitro and in vivo experiments and confirmed that flow in a tube of 0.35 mm in inner diameter can be detected.Attenuation measurement in 5-40 MHz and study on mechanisms of attenuation in biological tissue To show a feasibility to characterize a biological tissue from its frequency dependence of ultrasound attenuation, we developed a wide-band attenuation measurement system. From the results of measurements, it was concluded that ultrasound attenuation in a biological tissue is mainly due to tissue-organizing substances, such as protein and water, and the macroscopic structure of a tissue such as muscle fibers and that the cell structure of the tissue little contribute the attenuation.

在这项研究中，一个高频小型化的超声探头安装在穿刺针和成像系统，这种探头已经开发。该成像系统的有用性已在体外和体内实验中进行了评估。我们还研究了在高频区域使用超声衰减进行组织定征的可行性。获得了以下结果。小型化超声波探头和成像系统的开发已经开发了安装在16-20号穿刺针上的小型化探头，该穿刺针可以刺入组织中。一个2-D的超声图像，通过开发的成像系统在约6秒内获得。该系统的实用性通过模型和动物实验进行了检验。使用相关技术检测小血管中的血流成像系统被应用于使用相关技术检测身体深部小血管中的血流。为了评估这种流量检测方法，我们进行了体外和体内实验，并确认可以检测内径为0.35 mm的管道中的流量。5-40 MHz的衰减测量和生物组织中衰减机制的研究为了显示从超声衰减的频率依赖性来表征生物组织的可行性，我们开发了宽带衰减测量系统。根据测量结果，可以得出结论，生物组织中的超声衰减主要是由于组织组织组织物质，如蛋白质和水，以及组织的宏观结构，如肌肉纤维，而组织的细胞结构对衰减几乎没有贡献。