THE USEFULNESS AS BIOMATERIALS FOR RECONSTRUCTION OF JAW BONE OF APATITE PUTT

磷灰石 Putt 作为生物材料重建颌骨的用途

• 批准号: 10557190
• 负责人: UEYAMA Yoshiya
• 金额: $ 8.64万
• 依托单位: TOTTORI UNIVERSITY (2000)Okayama University (1998-1999)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-10557190/
• 关键词: apatite putty; beagle; long term; biocompatibility; bone substitution; powder X-ray diffraction; アパタイト; 組織親和性; アパタイトセメント; 動物実験; 炎症反応

A apatite putty which we developed behaves like a putty or self-curing resin, and is excellent in the operability. In view of the present experimental result which it was buried in the long term using a big animal, it was proved that it shows a excellent biocompatibility, and is early converted into apatite. The substitution to the bone occurs, however, merely only in the position which has slightly contacted with the existing bone, even if the apatite putty is early converted into the apatite. The apatite putty remains without replacing with most of the bone, even if one year passes and there seems to be seldom the possibility which the apatite putty will perfectly replace with the bone in future too. That is to say, the contact with mesenchymal cells is necessary in order for apatite putty to convert bone.Since this apatite putty converts into the apatite, it has the osteoconductivity and therefore, it adheres to the existing bone. However, it may not occur the perfect substitution to the bone, and it seems to remain for defective part of bone as an apatite. Therefore, it is considered that this apatite putty can be applied clinically. It is necessary, however, to examine the indication region of it further when it is used actually.

我们开发的磷灰石腻子的行为像果皮或自我固化树脂，并且在可操作性方面非常出色。鉴于目前使用大动物在长期内埋葬的实验结果，证明它表现出极好的生物相容性，并早期转化为磷灰石。但是，即使磷灰石腻子早期转化为磷灰石，替代骨骼的替代仅在与现有骨骼略有接触的位置发生。即使一年过去了，磷灰石油灰仍然没有替代大部分骨头，而且似乎很少有磷灰石腻子将来也可以完美地用骨头代替骨头。也就是说，必须与间充质细胞接触，以使磷灰石腻子转换骨头。由于该磷灰石腻子将其转换为磷灰石，它具有骨电导率，因此，它粘附在现有的骨骼上。但是，它可能不会出现完美的骨骼替代，并且似乎仍然是骨骼的缺陷部分。因此，可以认为可以在临床上应用此磷灰石腻子。但是，有必要在实际使用时进一步检查其指示区域。

项目成果

Y.Ueyama, K.Ishikawa, T.Mano, T.Koyama, K.Suzuki, T.Matsumura: "Initial tissue response to anti-washout apatite cement in the rat palatal region- Comparison with conventional apatite cement-"Journal of Biomedical Material research. in press. (2001)

Y.Ueyama、K.Ishikawa、T.Mano、T.Koyama、K.Suzuki、T.Matsumura：“大鼠腭区对抗冲刷磷灰石水泥的初始组织反应 - 与传统磷灰石水泥的比较 -”生物医学杂志

Y.Ueyama, K.Ishikawa, T.Mano, T.Koyama, H.Nagatsuka, T.Matsumura, K.Suzuku: "Tissue response to anrti-washout Apatite cement in the premaxilla of a rat"Bioceramies. Vol.11. 567-570 (1998)

Y.Ueyama、K.Ishikawa、T.Mano、T.Koyama、H.Nagatsuka、T.Matsumura、K.Suzuku：“大鼠前上颌骨中抗冲洗磷灰石水泥的组织反应”生物陶瓷。

Y Ueyama, K Ishikawa,T Mano,T Koyama et al: "Initial tissue response to anti-washout apatite cement in the rat palatal region-Comparison with conventional apatite cement-"Journal of Biomedical Materials Research. (2001)

Y Ueyama、K Ishikawa、T Mano、T Koyama 等人：“大鼠腭区对抗冲刷磷灰石水泥的初始组织反应 - 与传统磷灰石水泥的比较 -”生物医学材料研究杂志。

Y Ueyama,K Ishikawa,T Mano,T Koyama et al: "Tissue response to anti-washout apatite cement in the premaxilla of a rat"Biomaterials. 11. 567-570 (1998)

Y Ueyama、K Ishikawa、T Mano、T Koyama 等人：“大鼠前上颌骨中对抗冲刷磷灰石水泥的组织反应”生物材料。

Y Ueyama,K Ishikawa,T Mano,T Koyama et al: "Does apatite cement really replace with bone?"International Journal of Oral & Maxillofacial Surgery. 28. 106-106 (1999)

Y Ueyama、K Ishikawa、T Mano、T Koyama 等人：“磷灰石水泥真的能代替骨吗？”国际口腔杂志