THE USEFULNESS AS BIOMATERIALS FOR RECONSTRUCTION OF JAW BONE OF APATITE PUTT

研制的磷灰石腻子具有腻子或自固化树脂的性能，可操作性好。结合目前在大型动物体内长期埋藏的实验结果，证明其具有良好的生物相容性，能较早地转化为磷灰石。然而，对骨的替代只发生在与现有骨有轻微接触的位置，即使磷灰石腻子很早就转化为磷灰石。即使一年过去了，磷灰石腻子仍然没有取代大部分骨头，而且将来磷灰石腻子似乎也很少有可能完全取代骨头。也就是说，为了使磷灰石腻子转化成骨，与间充质细胞的接触是必要的。由于这种磷灰石腻子转化为磷灰石，它具有骨导电性，因此，它附着在现有的骨头上。然而，它可能不会发生骨的完美替代，它似乎作为磷灰石保留了骨的缺陷部分。因此，认为该磷灰石腻子可在临床上应用。然而，在实际使用时，有必要进一步研究其指示区域。

A apatite putty which we developed behaves like a putty or self-curing resin, and is excellent in the operability. In view of the present experimental result which it was buried in the long term using a big animal, it was proved that it shows a excellent biocompatibility, and is early converted into apatite. The substitution to the bone occurs, however, merely only in the position which has slightly contacted with the existing bone, even if the apatite putty is early converted into the apatite. The apatite putty remains without replacing with most of the bone, even if one year passes and there seems to be seldom the possibility which the apatite putty will perfectly replace with the bone in future too. That is to say, the contact with mesenchymal cells is necessary in order for apatite putty to convert bone.Since this apatite putty converts into the apatite, it has the osteoconductivity and therefore, it adheres to the existing bone. However, it may not occur the perfect substitution to the bone, and it seems to remain for defective part of bone as an apatite. Therefore, it is considered that this apatite putty can be applied clinically. It is necessary, however, to examine the indication region of it further when it is used actually.