Usefulness of alginate membrane added to osteoconductivity as GBR membrane

添加骨传导性的藻酸盐膜作为 GBR 膜的有用性

基本信息

批准号：
11470436
负责人：
UEYAMA Yoshiya
金额：
$ 9.41万
依托单位：
Tottori University (2000-2001)Okayama University (1999)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2001
项目状态：
已结题

项目摘要

We developed a new bioabsorbable alginate membrane which is applied directly to the surface of the bone defect, confirmed that it works as a barrier membrane in vivo. The purpose of the present study was to determine the appropriate concentration of sodium alginate and calcium chloride employed in the production of an alginate membrane. The thickness of alginate membranes increased with elevated sodium alginate concentration. The absorption of membrane, however, was delayed and the remained membrane prevented the bone formation.Moreover, there is a possibility that sodium alginate, which the bone defect is filled with, delays the new bone formation. Then, we examined the bone formation using the ready-made alginate membrane. The result was that a ready-made alginate membrane was broken and ingress of the connective tissue was observed for the bone defect at skin side. On the other hand, new bone formation was observed from the edge of preexisting cortical bone at muscle side. However, … More the shortening in the period of the new bone formation could not be accepted. Consequently, this ready-made alginate membrane was weak strength as well as conventional resorbable membrane.We added osteoconductivity to alginate membrane to shorten the period of bone regeneration : alginate membrane was made using sodium alginate including phosphate. In animal experiment, however, the period of bone regeneration in bone defect using alginate membrane including phosphate was not shortened compared with that using alginate membrane without phosphate. Conversely, the operation field using alginate membrane including phosphate occurred frequently inflammatory reaction, and then we understood that phosphate was affected as a material causing the inflammation.As a result, the appropriate concentration of sodium alginate and calcium chloride was each 3.0 % and 1 % so that alginate membrane works as a bioabsorbable barrier membrane. However, the experiment of adding osteoconductivity to alginate membrane did not success. Less

我们开发了一种新的可生物吸附藻酸盐膜，该膜直接应用于骨缺损的表面，证实它是体内的屏障膜。本研究的目的是确定在算法生产中进行的藻酸钠和氯化钙的适当浓度。藻酸盐膜的厚度随藻酸钠浓度升高而增加。然而，膜的痛苦被延迟，剩余的膜阻止了骨形成。此外，有可能填充骨缺损的藻酸钠会延迟新的骨形成。然后，我们使用现成的算法膜检查了骨形成。结果是破碎了现成的算法膜，并观察到与皮肤侧的骨缺损的连接组织的进入。另一方面，从肌肉侧先前存在的皮质骨边缘观察到了新的骨形成。但是，……无法接受新骨形成期间的缩短。因此，这种现成的藻酸盐膜的强度和常规的可吸收膜是弱的。我们为藻酸盐膜增添了骨连续性，以缩短骨再生周期：使用包括磷酸盐在内的藻酸钠制成藻酸盐膜。然而，在动物实验中，与使用无磷酸盐的藻酸盐膜相比，使用藻酸盐膜（包括磷酸盐）的骨骼缺损时期未缩短。相反，使用藻酸盐膜（包括磷酸盐）的操作场经常发生炎症反应，然后我们知道磷酸盐会受到引起炎症的材料的影响。结果，每个3.0％和1％的适当浓度是藻酸钠和氯化钙的适当浓度，因此藻酸盐膜可作为生物脱甲酸酯式链氨基甲贝型链氨基甲甲烷。然而，将藻酸盐膜添加骨导任的实验并未成功。较少的