The role of the basal ganglia in the bruxism and the development of the method for that estimation

基底神经节在磨牙症中的作用及其估计方法的开发

• 批准号: 10557164
• 负责人: MASUDA Yuji
• 金额: $ 6.78万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-10557164/
• 关键词: electrical stimulation; mastication; putamen; dopamine; 6OHDA; intake behavior; 大脳基底核; 被核; 淡蒼球; 咀嚼筋; イボテン酸; ウサギ; 大脳基底核咀嚼; 単一神経活動

It is still unknown how the bruxism are occurred and how the brain is involved in the bruxism. The aim of this project was to clarify the role of the basal ganglia in the bruxism. For this purpose we first examined whether the bruxism was able to be evoked experimentally or not, and secondly how the basal ganglia was involved in the oral function. Unfortunately we could not induce the bruxism either by stimulation to the basal ganglia or by making the basal ganglia lesion. Concerning the relationship between the mastication and the basal ganglia and also the nigrostriatal dopaminergic pathway, we obtained the findings in this study as follows ;1) It has been known that the masticatory sequence in the rabbit can be divided into three stages (stage I, IIa, IIb) based on the form of the jaw movements. It is found that electrical stimulation to the basal ganglia during stage II modulated the jaw movements. This result suggested that the basal ganglia might be involved in the alteration of the jaw movements according to the progress of masticatory sequence.2) Using the microdialysis method, the dopamine concentration in the putamen increased significantly during mastication compared with resting period. And the bilateral 6-hydroxydopamine lesions of the nigrostriatal dopaminergic pathway induced the change of the movement pattern during intake behavior. These results suggested that the nigrostriatal dopaminergic pathway might play a role in the sequential progress during the mastication.In this study, we showed the data, which suggested the basal ganglia might play a role in the control of orofacial fuctional behavior. We hope that our findings will be useful for the experiments studying the mechanism of the bruxism in the future.

磨牙症是如何发生的，以及大脑如何参与磨牙症，目前还不清楚。本研究旨在阐明基底神经节在磨牙症中的作用。为此，我们首先研究了磨牙症是否能够通过实验诱发，其次是基底神经节如何参与口腔功能。不幸的是，我们不能通过刺激基底神经节或通过基底神经节损伤来诱导磨牙症。关于咀嚼与基底神经节和黑质纹状体多巴胺能神经通路的关系，本研究获得如下结果：1）根据下颌运动的形式，兔的咀嚼顺序可分为三个阶段（Ⅰ、Ⅱ a、Ⅱ b期）。结果发现，电刺激基底神经节在第二阶段调制的下颌运动。结果提示，基底神经节可能参与了下颌运动随咀嚼顺序的变化。2）微透析法检测结果显示，咀嚼过程中壳核内多巴胺浓度较安静时显著升高。黑质纹状体多巴胺能通路的双侧6-羟多巴胺损伤引起摄食行为时运动模式的改变。这些结果提示黑质纹状体多巴胺能神经通路可能参与咀嚼运动的时序性过程，提示基底神经节可能参与口面功能行为的调控。我们希望我们的研究结果将有助于未来的实验研究磨牙症的机制。

项目成果

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