Role of striatal GABAergic neuron system in learning behavior

纹状体 GABA 能神经元系统在学习行为中的作用

基本信息

批准号：
11410022
负责人：
ICHITANI Yukio
金额：
$ 3.2万
依托单位：
University of Tsukuba
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11410022/
关键词：
striatum learning memory γ-aminobutyric acid GABA receptor rat

项目摘要

The striatum has been suggested to be involved not only in the sensory or motor control but also in cognitive function such as memory and learning. We have investigated the effects of striatal kainic acid lesions, which induce selective neuronal cell death in the striatum, on various kinds of learning behavior. Rats with striatal lesions showed severe deficits in spatial learning tasks though they did not show any deficits in discrimination learning and classical conditioning. The present study investigated the mechanism of learning deficits in these animals and the role of striatal neurons, especially striatal GABAergic neurons, in learning and memory.GABA_A agonist systemically administered before each trial significantly improved the performance of Morris water maze and radial maze tasks in rats with striatal kainic acid lesions, while GABA_B agonist did not. This suggests that GABA_A receptors in the brain are involved in the learning deficits of striatal lesioned animals. Since there are three areas to which striatal GABA neurons project, we then tested the effects of microinjection of GABA_A antagonist on radial maze behavior using normal rats previously trained in this task. As a result, injection into the substantia nigra pars reticulata most distinctly increased the number of errors, and injection into the striatum also had significant effects. Taken together it was suggested that a neural circuit containing the striatum, especially the strionigral GABAergic neuron system, plays an important role in performance of spatial memory tasks.

纹状体不仅参与了感觉或运动控制，还参与了认知功能，例如记忆和学习。我们已经研究了纹状体海藻酸病变的影响，这些纹状体菌株诱导纹状体中的选择性神经元细胞死亡对各种学习行为。患有纹状体病变的大鼠在空间学习任务中表现出严重的缺陷，尽管它们在歧视学习和经典条件方面没有显示出任何缺陷。本研究调查了这些动物中学习缺陷的机制以及纹状体神经元，尤其是纹状体GABA能神经元的作用，在学习和记忆中。gaba_a激动剂在每次试验之前都会进行系统的施用，显着改善了莫里斯水迷宫和radial radial radial radial radial contiatal Kainic Kainic Kainic Acid cainic Acid les__的表现。这表明大脑中的GABA_A受体参与了纹状体病变动物的学习缺陷。由于纹状体GABA神经元项目有三个领域，然后我们使用以前在此任务中接受过训练的正常大鼠测试了GABA_A拮抗剂对径向迷宫行为的显微注射的影响。结果，注射到黑质nigra pars enticulata最明显地增加了错误的数量，并且注入纹状体也有显着影响。综上所述，建议包含纹状体的神经回路，尤其是Srionigral Gabaergic神经元系统，在空间记忆任务的性能中起着重要作用。