Biopsychological study on the role of brain glutamate receptors in learning and memory

脑谷氨酸受体在学习记忆中作用的生物心理学研究

• 批准号: 09410021
• 负责人: ICHITANI Yukio
• 金额: $ 4.22万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09410021/
• 关键词: learning; memory; glutamate receptor; NMDA receptor; hippocampus; rat; グルタミン酸; NMDA受容体; 線条体

Although it has recently been suggested that NMDA receptors are associated with memory and learning, there has been only a few behavioral studies on the role of NMDA receptors in specific brain regions. In this study, using radial maze learning task and a microinjection technique of specific agonists and antagonists, we investigated the role of brain NMDA receptors in spatial memory.We first tested the effects of intrahippocampal microinjection of competitive and non-competitive NMDA receptor antagonists (AP5 and MK-801, respectively) on the rats' performance in radial maze. Both of them markedly impaired the correct performance while the AP5 treatment into the striatum did not have any effect on radial maze performance, suggesting that NMDA receptors in the hippocampus play an important role in spatial memory.NMDA receptors consist of several subcomponents. We tested the effects of intrahippocampal treatment of DCS, a glycine-site agonist, on spatial memory deficits in radial maze task produced by systemic MK-801. DCS improved the MK-801-induced performance impairment, suggesting that glycine sites are involved in spatial memory through their modulatory action on hippocampal NMDA receptors.

尽管最近有人提出NMDA受体与记忆和学习有关，但关于NMDA受体在特定大脑区域的作用的行为研究只有少数行为研究。在这项研究中，使用径向迷宫学习任务以及特定激动剂和拮抗剂的微注射技术，我们研究了脑NMDA受体在空间记忆中的作用。我们首先测试了竞争性和非竞争力的NMDA受体拮抗剂（AP5和MK-801）的竞争性和非竞争力的NMDA受体拮抗剂的竞争性和非竞争力的NMDA受体拮抗剂的影响。他们俩都显着损害了正确的性能，而AP5治疗对纹状体的处理对径向迷宫的性能没有任何影响，这表明海马中的NMDA受体在空间内存中起重要作用。NMDA受体由几个子组成部分组成。我们测试了甘氨酸位点激动剂DC的汉皮接管治疗对全身MK-801产生的径向迷宫任务中空间记忆缺陷的影响。 DC改善了MK-801诱导的性能障碍，这表明甘氨酸位点通过其对海马NMDA受体的调节作用参与了空间记忆。

项目成果

Kawabe,K.: "Intrahippocampal D-cycloserine improves MK-801-induced memory deficits : radial-arm maze performance in rats." Brain Research. 814. 226-230 (1998)

Kawabe,K.：“海马内 D-环丝氨酸改善 MK-801 诱导的记忆缺陷：大鼠径向臂迷宫表现。”

Nonaka,H.: "Effects of early postnatal AF64A treatment on passive avoidance response and radial maze. learning in rats." Japanese Journal of Psychopharmacology. 18. 39-44 (1998)

Nonaka, H.：“出生后早期 AF64A 治疗对大鼠被动回避反应和径向迷宫学习的影响。”

Kouichi Kawabe et al.: "Intrahippocampal D-cycloserine improves MK-801-induced memory deficits : radial-arm maze performance in rats." Brain Research. 814. 226-230 (1998)

Kouichi Kawabe 等人：“海马内 D-环丝氨酸改善 MK-801 诱导的记忆缺陷：大鼠径向臂迷宫表现。”

山田 一夫: "慢性ストレスによる海馬の形態的・機能的変化に関する研究の動向" 筑波大学心理学研究. 20. 51-58 (1998)

Kazuo Yamada：“慢性压力导致的海马形态和功能变化的研究趋势”筑波大学心理学研究 20. 51-58 (1998)。

Kawabe,K. 一谷幸男: "Effects of intrahippocampal AP5 treatment on radial-arm mage performance in rats." Brain Research. (印刷中). (1998)

Kawabe, K. Yukio Ichitani：“海马内 AP5 治疗对大鼠桡臂法师表现的影响”（出版中）。