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Flow nuclear magnetic resonance spectrometer

流式核磁共振波谱仪

基本信息

批准号：
456121295
负责人：
金额：
--
依托单位：
Georg-August-Universität Göttingen
依托单位国家：
德国
项目类别：
Major Research Instrumentation
财政年份：
2021
资助国家：
德国
起止时间：
2020-12-31 至无数据
项目状态：
未结题

来源：
https://gepris.dfg.de/gepris/projekt/456121295?language=en
关键词：
Flow nuclear magnetic resonance spectrometer

项目摘要

Resource-economic and sustainable synthetic strategies are of key importance for modern organic chemistry. Especially the activation of C–H and C–C bonds offers a powerful tool for the efficient assembly of structural complex molecules. The development of novel, biologically active, in particular anti-viral compounds via C–H activation, require fast optimization methods and easily scalable reaction conditions. Direct in-operando reaction monitoring has the power to accelerate this process significantly. Hence, it is essential for the research groups of the Institute for Organic and Biomolecular Chemistry to have access to a high-resolution flow-NMR-spectrometer. The envisioned projects i) electrochemical C–H activation in flow, ii) photo-flow reactions, iii) late-stage functionalization of peptides, iv) synthesis of bioactive molecules in flow, and v) development of a substrate library for studies with COVID 19 require a fast optimization and an in-depth mechanistic understanding to establish ideal reaction conditions. Unfortunately, thus far a high-resolution flow-NMR-spectrometer is not available at the Georg-August-Universität Göttingen. This instrument allows for the exact investigations of reactions as to the formation of the target and coupling products, as well as the reaction kinetics and nature of key intermediates. The excellent resolution of a high-resolution spectrometer enables meticulous kinetic studies of challenging reactions and thus valid insights for the optimization and understanding of catalytic transformations.

资源节约型和可持续发展的合成策略是现代有机化学的关键。尤其是C-H和C-C键的活化，为结构复杂分子的高效组装提供了有力的工具。开发新型的生物活性化合物，特别是通过C-H活化的抗病毒化合物，需要快速的优化方法和易于扩展的反应条件。直接监测手术中的反应可以显著加速这一过程。因此，有机和生物分子化学研究所的研究小组必须能够获得高分辨率的流动核磁共振光谱仪。设想的项目i)流动中的电化学C-H活化，ii)光流反应，iii)肽的后期官能化，iv)流动中生物活性分子的合成，以及v)开发用于COVID 19研究的底物文库，需要快速优化和深入的机理理解以建立理想的反应条件。不幸的是，到目前为止，乔治-奥古斯特-哥廷根大学还没有高分辨率的流动核磁共振光谱仪。该仪器可对目标产物和偶联产物的形成以及关键中间体的反应动力学和性质进行准确的反应研究。高分辨率光谱仪的出色分辨率使我们能够对具有挑战性的反应进行细致的动力学研究，从而为优化和理解催化转化提供有效的见解。