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Research on thermal analysis and thermal enhancement effect in loco-regional hyperthermia by means of thermosimulation

热模拟局部热疗的热分析及热强化效果研究

基本信息

批准号：
11470195
负责人：
TANAKA Yoshiaki
金额：
$ 5.38万
依托单位：
Nihon University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2002
项目状态：
已结题

项目摘要

Hyperthermia is an effective modality in cancer treatment especially combined with radiotherapy. However, it is difficult to analyze the relation between thermal parameters and treatment outcome. Thermo-simulation system has been introduced and applied to analyze the thermal factors. Nineteen patients were treated with thermo-radiotherapy using RF capacitive heating system (Thermotron-RF8). Hyperthermia was performed once or twice per week with total 2 to 7 heating sessions and applied with average RF output of 359-1150W and average heating time of 50 minutes. Radiation therapy was given with 2 Gy/fx in 5 fx/week and median dose of 50 Gy. Tb apply thermosimulator, average intensity of RF power supply and heating time were calculated on each patient. Thermal distribution were obtained and displayed every minute on CT images, and thermal factors were analyzed regarding the relation between the local response and relapse free survival time.All thermal factors of patients achieving CR and PR were longer than those in patients achieving NC, but these differences were not significant. The CR and PR rate was 75% in patients in whom EM43T90 was more than 4, and 45% in those where it was less than 4. This rate was 67% in patients in whom teq43T90 was more than 2, and 50% in those where it was less than 2. Median recurrence-free survival time was 5.5 months in patients in whom EM43T90 was more than 4, and 3.6 months in those where it was less than 4. This difference was not significant. In a proportional hazard model, factors that significantly influenced recurrence-free survival time were EM43T90, EM43T50, teq43T90, teq43T50, and histology. After determining thermal factors through a thermo-simulation technique, these factors were demonstrated to have a tendency to influence thermoradiotherapy outcome. Especially, EM43T90 and teq43T90 were the most useful thermal factors to predict treatment outcome.

热疗是一种有效的癌症治疗方式，特别是与放射治疗相结合。然而，很难分析热参数和治疗结果之间的关系。介绍了热模拟系统并应用于热因素分析。19例患者使用射频电容加热系统（Thermotron-RF 8）进行热放疗。每周进行一次或两次热疗，共2至7次加热，平均射频输出为359- 1150 W，平均加热时间为50分钟。放疗剂量2戈伊/次，每周5次，中位剂量50戈伊。应用热模拟器，计算每例患者的平均射频功率强度和加热时间。在CT图像上每分钟获取并显示热分布，分析热因素与局部反应和无复发生存时间的关系，CR和PR患者的各项热因素均长于NC患者，但差异无统计学意义。EM 43 T90> 4的患者CR和PR率为75%，EM 43 T90 <4的患者CR和PR率为45%。在teq 43 T90大于2的患者中，这一比率为67%，在teq 43 T90小于2的患者中，这一比率为50%。EM 43 T90大于4的患者中位无复发生存时间为5.5个月，EM 43 T90小于4的患者中位无复发生存时间为3.6个月。这种差异不显著。在比例风险模型中，显著影响无复发生存时间的因素为EM 43 T90、EM 43 T50、teq 43 T90、teq 43 T50和组织学。通过热模拟技术确定热因素后，这些因素被证明有影响热放疗结果的趋势。其中，EM 43 T90和teq 43 T90是预测治疗结果最有用的热因子。