Protective Effect of New Enteral Nutritional Formula including Whey Protein Hydrolysate against Indomethacin-Induced Ulceration in Rats

含乳清蛋白水解物的新型肠内营养配方对吲哚美辛引起的大鼠溃疡的保护作用

• 批准号: 11470264
• 负责人: NAKASAKI Hisao
• 金额: $ 6.91万
• 依托单位: Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11470264/
• 关键词: whey protein hydrolysate; enteral nutrition; rats; indomethacin-induced ulcers; anti-ulcer properties; 潰瘍性大腸炎; アミノ酸栄養剤; 経腸栄養; 乳清ペプチド; 脂肪酸

A new enteral nutritional formula containing whey protein hydrolysate (WPH) was evaluated its suppressive effect on indomethacin-induced ulcers. The first experiment resulted less intestinal ulcers appearance (1/7) in Sprague-Dawley male rats which received subcutaneous indomethacin administration or WPH formula feeding period than in those fed the formulas containing amino acids(4/6) and intact protein (6/7) as nitrogen source. In the second experiment, rats were cross-fed on different formulas, less intestinal ulcers appeared in rats pre-fed WPH formula. (1/7 in pre WPH- post WPH, 1/8 in WPH-AA, 6/7 in AA-WPH, 5/7 in AA-AA). Similar results were also shown in cecum ulcers. These results suggest that the WPH formula would have some property suppressing indomethacin-induced ulcers.

研究了一种含乳清蛋白水解物（WPH）的新型肠内营养配方对消炎痛所致溃疡的抑制作用。第一个实验导致接受皮下注射吲哚美辛或WPH配方喂养期的Sprague-Dawley雄性大鼠的肠溃疡出现率（1/7）低于喂食含有氨基酸（4/6）和完整蛋白质（6/7）作为氮源的配方的大鼠。实验二采用不同配方的饲料进行交叉喂养，结果表明，预喂WPH配方的大鼠出现肠溃疡的次数较少。（WPH前-WPH后为1/7，WPH-AA为1/8，AA-WPH为6/7，AA-AA为5/7）。在盲肠溃疡中也显示了类似的结果。这些结果表明，WPH配方将具有抑制吲哚美辛诱导的溃疡的某些特性。

项目成果

上田善継 他: "乳清タンパク質加水分解物を用いた経腸栄養剤のラットにおけるインドメタシン潰瘍予防効果"日本栄養・食糧学会誌に. (発表予定).

Yoshitsugu Ueda 等人：“使用乳清蛋白水解物的肠内营养对预防大鼠吲哚美辛溃疡的效果”，发表在日本营养与食品科学学会杂志（待出版）中。

Protective Effect of New Enteral Nutritional Formula including Whey Protein Hydrolysate against Indomethacin-Induced Ulceration in Rats. (in press).

包含乳清蛋白水解物的新型肠内营养配方对吲哚美辛引起的大鼠溃疡的保护作用。

上田善継 他: "乳清タンパク質加水分解物を用いた経腸栄養剤のラットにおけるインドメタシン潰瘍予防効果"日本栄養・食糧学会誌. (発表予定).

Yoshitsugu Ueda 等人：“使用乳清蛋白水解物进行肠内营养对预防大鼠吲哚美辛溃疡的效果”，日本营养与食品科学学会杂志（待发表）。