Trial of enhancement in lyngbatic organ activety during TPN using PSK

使用 PSK 增强 TPN 期间淋巴器官活性的试验

• 批准号: 03670643
• 负责人: NAKASAKI Hisao
• 金额: $ 1.28万
• 依托单位: Tokai Univ, School of medicine . Dept. Surg II
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03670643/
• 关键词: TPN; S-IgA; PSK; Bacterial Translocation; リンパ球サブセット; 消化管リンパ節; BRM; 消化管廃用性萎縮; 経中漢静脈高カロリ-輸液; Biological Response Modifier; パイエル板; helper; inducer T; suppressor; cytotoxic T

In 1991, we made a study of the influence of the method of feeding by central venous catheter, and obtained the following results.1)The method of feeding by central venous catheter causes the atrophy of the mucus of the digestive tract.2)Dosage of PSK prevents the decrease of agmen peyerianum and also normalizes the internal distribution of immunological cells.In 1992, we studied how the method of feeding by central venous catheter (in TPN group) affects the immunological system.1)S-IgA in gall2)S-IgA in portal venous blood3)Bacterial translocation to mesenteric lymph nodes respectively studied.ResultsThe bacteriological study of mesenteric lymph nodes revealed that bacteria were detected at a higher rate in TPN group compared with the control groupThere was no difference in endotoxin concentration in portal venous blood.Less S-IgA was detected in gall and portal venous blood in TPN group.In the study of distribution of immunological cells in the mucus of digestive tract, the test result implied a fall in immunocompetence in TPN group.Conclusion/reviewThe immunocompetence at digestive tract was lowered by using TPN for a long term. The dosage of BRM such as PSK is effective against these falls.

1991年，我们对中心静脉置管喂养方式的影响进行了研究，得到以下结果：1)中心静脉置管喂养方式引起消化道粘液萎缩；2)PSK剂量可阻止黑胆汁的减少，并使免疫细胞的内部分布趋于正常。1)门静脉血中S-Ig A；2)门静脉血中S-Ig A；3)肠系膜淋巴结细菌易位。结果细菌学检查显示，TPN组肠系膜淋巴结细菌检出率高于对照组。门静脉血内毒素浓度无差异。TPN组胆汁和门静脉血中S-Ig A检测较少。在消化道粘液中免疫细胞分布的研究中，TPN组免疫功能下降。结论：长期使用TPN可降低消化道免疫功能。剂量的BRM，如PSK，对这些跌倒是有效的。

项目成果

Hitoshi HANAUE,Akira OKUMURA,Kohsi KANNO,Tomoo TAJIMA and Toshio MITOMI: "The Effect of a ProteinーBound Polysaccharide on T Cell Subsets of Peripheral Venous Blood and Thoracic Duct Lymph" Tokai J Exp Clin Med. 16. 163-169 (1991)

Hitoshi HANAUE、Akira OKUMURA​​、Kohsi KANNO、Tomoo TAJIMA 和 Toshio MITOMI：“蛋白质结合多糖对外周静脉血和胸导管淋巴 T 细胞亚群的影响”Tokai J Exp Clin Med 16. 163-169 (1991) ）

H.Hanaue: "The effect of a protein-bound polysaccharide(PSK) on lymph cyte subsets in normal rat" Except Medica. (1992)

H.Hanaue：“蛋白质结合多糖 (PSK) 对正常大鼠淋巴细胞亚群的影响”，Medica 除外。

Hitoshi Hanaue: "The effect of a protein-Bound polysaccaride on Tcell subsets of Deripheral Venous Blood and Thoracic Duet lymph" Tokai J.Exp Clin,Med. 16. 163-169 (1991)

Hitoshi Hanaue：“蛋白质结合多糖对下肢静脉血和胸二叶淋巴 T 细胞亚群的影响”Tokai J.Exp Clin，Med。

花上 仁: "経中心静脉高カロリー輸液がもたらす消化管付属リンパ組織の機能低下とその対策" 消化器と免疫. 27. 93-98 (1992)

Hitoshi Hanagami：“经中枢平静高热量输注引起的胃肠道相关淋巴组织功能下降及其对策”《胃肠与免疫学》27. 93-98 (1992)。

花上 仁,田島 知郎,三富 利夫: "経中心静脈高カロリ-輸液がもたらす消化管付属リンパ組織の機能低下と対策" 第27回消化器と免疫 研究会 プログラム・抄録. 4-4 (1992)

Hitoshi Hanagami、Tomoro Tajima、Toshio Mitomi：“经中心静脉高热量输注引起的胃肠道相关淋巴组织的功能下降及对策”第27届胃肠和免疫学研究组计划摘要（1992）4-4）。