Study on the effects of estrogen on the brain 〜 comprehensive analysis using MRI

研究雌激素对大脑的影响~利用MRI进行综合分析

基本信息

批准号：
11470345
负责人：
ASO Takeshi
金额：
$ 9.28万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2001
项目状态：
已结题

项目摘要

1) The effects of ovarian hormone on autoregulatory function in cerebral blood flow (CBF) were investigated using blood oxygenation level dependent (BOLD) MRI. CBF increases in response to anoxia challenge were greater in female rats than in male and ovariectomized female rats. This finding indicates that ovarian hormone may play an important role in autoregulation of cerebral perfusion.2) The effects of ovarian hormone on the time course changes in the cytotoxic brain edema after cerebral ischemia were investigated using diffusion weighted MR imaging. The extent of cytotoxic edema after middle cerebral artery occlusion increased in male and ovariectomized female rats, whereas it decreased in female rats This finding indicates that ovarian hormone favorably works in ischemic penumbra.3) MR parameters in brain at various ages in rats were measured by experimental MR imager and compared with the water contents and histological findings. Transverse relaxation time and apparent diffusion coefficients decreased in proportion to aging and the parameters showed a significant correlation with brain water contents. Whereas, fractional anisotropy increased in proportion to aging and well correlated with myelination. These findings indicate that the development and aging of the brain can be evaluated using multi-parametric MRI in vivo.4) the effects of estrogen and progesterone on spatial memory function were investigated using an eight-radial maze. Spatial memory function was significantly disturbed in ovariectomized rats, but it was ameliorated by estrogen supplementation. Cognitive impairment by scopolamine injection was significantly reduced in estrogen-treated, progesterone-treated and estrogen-progesterone-treated ovariectomized rats than in ovariectomized rats. Not only estrogen but also progesterone had neuroprotective action against scopolamine-induced impairment of working memory.

1）使用血液氧合水平（BOLD）MRI研究了卵巢激素对脑血流（CBF）自动调节功能的影响。雌性大鼠的CBF对缺氧挑战的响应增加比男性和卵巢雌性大鼠更大。这一发现表明，卵巢激素可能在脑灌注自动调节中起重要作用。2）使用扩散加权MR成像研究了卵巢激素对脑缺血后细胞毒性脑湿气的时间疗法的影响。雄性和卵巢切除型雌性大鼠的大脑中动脉闭塞后的细胞毒性水肿的程度增加，而女性大鼠的减少，这一发现表明，在各种Ages中，大脑中的大脑中的卵巢激素在脑部的MR参数中有利地作用于实验MR的MR Imagers，并与饮水相比，在大鼠中的大脑中有效。横向松弛时间和明显的扩散系数与衰老成比例降低，并且参数显示与脑水含量显着相关。而分数各向异性与衰老成比例增加，并且与髓鞘相关。这些发现表明，可以使用多参数MRI在体内评估大脑的发育和衰老。4）使用八个radial迷宫研究了雌激素和孕酮对空间记忆功能的影响。在卵巢切除大鼠中，空间记忆功能受到显着干扰，但补充雌激素可以改善。在雌激素治疗，经孕激素治疗和雌激素 - 促剂治疗的卵巢骨切除术大鼠中，海pol骨注射的认知障碍显着降低了，而不是在卵巢切除的大鼠中。不仅雌激素，而且孕酮还针对西pol骨引起的工作记忆损害具有神经保护作用。