Investigation on main sources of persistent organic pollutants(POPs) in human breast milk

母乳中持久性有机污染物（POPs）主要来源调查

基本信息

批准号：
14370130
负责人：
MIYATA Hideaki
金额：
$ 4.99万
依托单位：
Setsunan university
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2003
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14370130/
关键词：
Breast milk Meal Dioxin analogues Coplanar PCBs Infant Pollution source PCDDs PCDFs コプラナーPCB 乳児残留性有機汚染物質

项目摘要

In general, the level of dioxin analogues dioxin analogues, which are composed of polychlorinated dibenzo-p-dioxins(PCDDs), polycldorinated dibenzoftirans(PCDFs) and coplanar PCBs(Co-PCBs), in human breast milk is considered to be reflecting to their accumulation level in the body. In addition, it is well known that ca. 60% of their body storage is excreted to the baby through breast milk by nursing for a year. In 2001, however, we found that there was a great difference in a time alteration of daily decrease rate of PCDDs and PCDFs in breast milk from 7 nursing mothers and that their level in breast milk did not always decrease with time passing after delivery. This indicates that some part of dioxin analogues in milk might be delivered from other sources except for their storage in the body. Therefore, in this study, we investigated to, detect their main source of pollutants in human breast milk.Eight breast milk samples were daily obtained at a rate of once per every 3 hours in a pe … More riod of consecutive four days from 10 nursing mothers. In addition, three dietary samples were also daily obtained in the three time windows of morning(breakfast to until lunch time), day (lunch to until dinner) and night(dinner to until breakfast) from the same mothers. The body weight of babies were weighed at an every time of before and after of their milk intake, in order to detect their intake amount of milk. In the first day of experiment, 70ml of blood was sampled at hungry time such as at first three hours after meal, in to detect the body storage of dioxin analogues in tested mothers.Both the pollution level and composition ratio of dioxin analogues in the breast milk altered in a time course. The alteration was seen in all tested mothers. In addition, the composition ratio of PCDDs,. PCDFs and Co-PCBs in the milk differed frequently from that of the blood at a hungry time, which is considered to reflect on the actual pollution condition of their body storage. There was. observed a great discrepancy in the time alteration concerning pollution level and composition even within a day. From these results, we confirmed that the pollution of dioxin analogues in the breast milk is influenced by meal except for the body storage.Compared to the breast milk, meal samples showed a more remarkable time alteration on the pollution level and constituent of dioxin analogues. Especially, the dietary sample including fish and/or meat gave a high pollution level of dioxin analogues, showing fish to elevate particularly Co-PCB in comparison with PCDDs and PCDFs. Intake amounts of dioxin analogues by mother via dietary and by infant via breast milk were calculated on the bases of analytical data and infant's milk intake. Taking both the intake amounts into consideration, it was revealed that the dietary intake of dioxin analogues gave some degree of influence on the pollution level in the first and second nursing breast milks after the meal. The transfer rate was 10〜100%. This is the first discovery in the world. In addition, we also insist that the breast milk is not a suitable sample as an indicator for assessment of human exposure to dioxin analogues. In case of Co-PCBs as a major constituent among dioxin analogues in the dietary sample, it was confirmed that Co-PCBs with a short half biological half life and a low bio-accumulative ability could preferably transfer from dietary sample to breast milk. Less

通常，由多氯联苯二苯二唑 - 二恶英（PCDD），多二氧化烷基化的二苯并二苯并二氧蛋白（PCDFS）和Coplanar PCB（Co-PCB）组成的二恶英类似物的水平，在人体母乳中被认为反映了其在体内的积累水平。另外，众所周知CA。通过护士一年，通过母乳超过了婴儿的60％的身体储存。但是，2001年，我们发现，从7名护士母亲的母乳中，每天的PCDD和PCDF的时间变化率有很大差异，并且母乳中的母乳中的水平并不总是随着分娩后的时间而降低。这表明牛奶中的某些部分类似物可能是从其他来源传递出来的。因此，在这项研究中，我们调查了它们在人类母乳中的主要污染物来源。每天在PE中以每3小时的每3小时每3小时的速度获得8天的母乳样品……从10位护士母亲那里进行了四天的连续四天。此外，每天在早上的三个窗户（早餐到午餐时间），白天（午餐至晚餐）和晚上（晚餐到早餐）每天还能获得三个饮食样本。为了检测出牛奶的摄入量，婴儿的体重在牛奶摄入之前和之后的每一次都会加权。在实验的第一天，在饥饿的时间（例如在饭后三个小时）取样了70毫升的血液，以检测到测试母亲中二恶英类似物的体内储存。包括在时间过程中，母乳中二恶英类似物的污染水平和组成比率。在所有经过测试的母亲中都可以看到这种改变。另外，PCDD的组成比。牛奶中的PCDF和Co-PCB与饥饿的时间经常不同，这被认为反映了其身体储存的实际污染状况。有。观察到甚至在一天之内，关于污染水平和成分的时间变化的巨大差异。从这些结果中，我们证实，除了身体储存外，母乳中二恶英类似物的污染受到母乳的影响，餐样品在污染水平和二恶英类似物的构成上显示出更为明显的时间改变。尤其是，包括鱼类和/或肉在内的饮食样本给出了高污染的二恶英类似物，与PCDD和PCDF相比，鱼类特别升高了co-PCB。在分析数据和婴儿牛奶摄入量的基础上计算了母亲通过饮食和婴儿通过母乳的摄入量的二恶英类似物。考虑到两种摄入量，据显示，二恶英类似物的饮食摄入量对餐后的第一和第二哺乳乳房中对污染水平产生了一定程度的影响。转移率为10-100％。这是世界上的第一个发现。此外，我们还坚持认为，母乳不是适合评估人类对二恶英类似物的指标。如果Co-PCB作为饮食样本中的二恶英类似物中的主要构成，则可以证实，一半生物学半寿命且生物蓄积能力低的co可以优先从饮食样本转移到母乳。较少的