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Investigation on main sources of persistent organic pollutants(POPs) in human breast milk

母乳中持久性有机污染物（POPs）主要来源调查

基本信息

批准号：
14370130
负责人：
MIYATA Hideaki
金额：
$ 4.99万
依托单位：
Setsunan university
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2003
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14370130/
关键词：
Breast milk Meal Dioxin analogues Coplanar PCBs Infant Pollution source PCDDs PCDFs コプラナーPCB 乳児残留性有機汚染物質

项目摘要

In general, the level of dioxin analogues dioxin analogues, which are composed of polychlorinated dibenzo-p-dioxins(PCDDs), polycldorinated dibenzoftirans(PCDFs) and coplanar PCBs(Co-PCBs), in human breast milk is considered to be reflecting to their accumulation level in the body. In addition, it is well known that ca. 60% of their body storage is excreted to the baby through breast milk by nursing for a year. In 2001, however, we found that there was a great difference in a time alteration of daily decrease rate of PCDDs and PCDFs in breast milk from 7 nursing mothers and that their level in breast milk did not always decrease with time passing after delivery. This indicates that some part of dioxin analogues in milk might be delivered from other sources except for their storage in the body. Therefore, in this study, we investigated to, detect their main source of pollutants in human breast milk.Eight breast milk samples were daily obtained at a rate of once per every 3 hours in a pe … More riod of consecutive four days from 10 nursing mothers. In addition, three dietary samples were also daily obtained in the three time windows of morning(breakfast to until lunch time), day (lunch to until dinner) and night(dinner to until breakfast) from the same mothers. The body weight of babies were weighed at an every time of before and after of their milk intake, in order to detect their intake amount of milk. In the first day of experiment, 70ml of blood was sampled at hungry time such as at first three hours after meal, in to detect the body storage of dioxin analogues in tested mothers.Both the pollution level and composition ratio of dioxin analogues in the breast milk altered in a time course. The alteration was seen in all tested mothers. In addition, the composition ratio of PCDDs,. PCDFs and Co-PCBs in the milk differed frequently from that of the blood at a hungry time, which is considered to reflect on the actual pollution condition of their body storage. There was. observed a great discrepancy in the time alteration concerning pollution level and composition even within a day. From these results, we confirmed that the pollution of dioxin analogues in the breast milk is influenced by meal except for the body storage.Compared to the breast milk, meal samples showed a more remarkable time alteration on the pollution level and constituent of dioxin analogues. Especially, the dietary sample including fish and/or meat gave a high pollution level of dioxin analogues, showing fish to elevate particularly Co-PCB in comparison with PCDDs and PCDFs. Intake amounts of dioxin analogues by mother via dietary and by infant via breast milk were calculated on the bases of analytical data and infant's milk intake. Taking both the intake amounts into consideration, it was revealed that the dietary intake of dioxin analogues gave some degree of influence on the pollution level in the first and second nursing breast milks after the meal. The transfer rate was 10〜100%. This is the first discovery in the world. In addition, we also insist that the breast milk is not a suitable sample as an indicator for assessment of human exposure to dioxin analogues. In case of Co-PCBs as a major constituent among dioxin analogues in the dietary sample, it was confirmed that Co-PCBs with a short half biological half life and a low bio-accumulative ability could preferably transfer from dietary sample to breast milk. Less

一般来说，母乳中二恶英类似物(由多氯二苯并-对二恶英(PCDDs)、多氯二苯并呋喃(PCDf)和共面多氯联苯(Co-PCbs)组成)的水平被认为反映了它们在体内的积累水平。此外，众所周知，大约60%的身体存储是通过哺乳一年的母乳排泄给婴儿的。但在2001年，我们发现7名哺乳母亲母乳中PCDDs和PCDFs的日下降率随时间的变化有很大差异，产后母乳中PCDDs和PCDFs的水平并不总是随着时间的推移而下降。这表明，牛奶中的二恶英类似物的一部分可能来自其他来源，而不是储存在体内。因此，在本研究中，我们调查了它们在母乳中的主要污染源。每天在PE…中以每3小时一次的速度采集8份母乳样本10名哺乳母亲连续4天产后出院。此外，在上午(早餐到午餐时间)、白天(午餐到晚餐)和晚上(晚餐到早餐)这三个时间窗口，也每天从同一母亲那里获得三个膳食样本。婴儿每次摄奶前后均称量体重，以测定其摄奶量。在实验的第一天，在饥饿的时候，例如在餐后三小时内，采集70ml的血液，以检测受试母亲体内二恶英类似物的储存情况。母乳中二恶英类似物的污染水平和构成比都随着时间的变化而变化。在所有接受测试的母亲身上都能看到这种变化。此外，还测定了PCDDs、.牛奶中的多氯二苯并呋喃和多氯联苯在饥饿时与血液中的多氯联苯经常不同，这被认为反映了它们身体储存的实际污染状况。是有的。即使在一天之内，观测到的污染水平和组成的时间变化也有很大的差异。结果表明，母乳中二恶英类似物的污染受膳食的影响，但与母乳相比，膳食样品对二恶英类似物的污染水平和组成有更显著的时间变化。特别是，包括鱼和/或肉类的饮食样本中二恶英类似物的污染水平很高，与多氯二苯并二恶英和多氯二苯并呋喃相比，鱼类的二恶英类似物含量特别高。根据分析数据和婴儿的牛奶摄入量，计算了母亲通过饮食摄入二恶英类似物，婴儿通过母乳摄入二恶英类似物的量。综合考虑两者的摄入量，发现饮食中二恶英类似物的摄入量对餐后第一次和第二次哺乳母乳的污染水平有一定的影响。转移率为10%~100%。这是世界上的第一次发现。此外，我们也坚持母乳不适合作为评估人类接触二恶英类似物的指标。在食物样本中的二恶英类似物中以Co-PCbs为主的情况下，证实生物半衰期短、生物累积能力低的Co-PCbs可以较好地从食物样本转移到母乳中。较少