Investigation of current situation and pollution source of human body contamination for highly toxic bromine system dioxins

高毒溴系二恶英人体污染现状及污染源调查

• 批准号: 16390173
• 负责人: MIYATA Hideaki
• 金额: $ 5.76万
• 依托单位: Setsunan University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390173/
• 关键词: Bromine system dioxins; Dioxins; Brominated flame retardant; Breast milk; Meal; Polybrominated diphenyl ethers; Powdered milk; Analysis; 人体汚染; 臭素化ダイオキシン類; 臭素化塩素化ダイオキシン類; 血液; 汚染源

In this research, the high precision trace analytical methods for all the bromine system dioxins and brominated flame retardants were first developed. Next, by using these analytical methods, the current pollution situation of bromine system dioxins and brominated flame retardants was clearly clarified about blood, breast milk, a meal, food, etc. The pollution of breast milk by the polybrominated diphenyl ethers (PBDEs) which are the main pollution sources of bromine system dioxins showed clearly that the transient influence by dietary intake was received. This new knowledge suggests that pollution of breast milk is mitigable by taking in suitable food stuffs with little contamination. In addition, the difference of the pollution actual condition in primiparae and multiparae was clarified about PBDEs of brominated flame retardants, tetrabromobisphenol A, tribromophenol, brominated/chlorinated dioxins, and brominated dioxins. On the other hand, the pollution rate of the brominated/chlorinated dioxins which occupies breast milk to dioxin toxicity equivalency quantity (TEQ) compared with artificial milk or milk had changed into the quite high state, showing a possibility that the cause of pollution originated in a dwelling. Even at breast-feeding of a short time for about 30 minutes in stomach empty period with little influence of a meal, the concentration and the composition ratio of PBDEs in mother's milk were changed sharply. This result suggests the complicated action of PBDEs accumulated into a human body. As mentioned above, some precious new findings were able to obtain in this research. It is sure that these results can greatly contribute to the measure against mitigation to future human body contamination, suckling contamination, environmental pollution, food contamination, etc.

本研究首次开发了溴系二恶英和溴系阻燃剂的高精度痕量分析方法。接下来，利用这些分析方法，明确了血液、母乳、膳食、食物等中溴系二恶英和溴系阻燃剂的污染现状。作为溴系二恶英主要污染源的多溴二苯醚(PBDEs)对母乳的污染清楚地表明，受到饮食摄入的短暂影响。这一新知识表明，通过摄入污染很少的合适食物，可以减轻母乳污染。此外，还明确了初产妇和经产妇的溴化阻燃剂、四溴双酚A、三溴苯酚、溴化/氯化二恶英、溴化二恶英等PBDEs污染现状的差异。另一方面，与人工奶或牛奶相比，母乳中的溴化/氯化二恶英对二恶英毒性当量（TEQ）的污染率已转变为相当高的状态，表明污染原因可能源于住宅。即使在几乎没有进餐影响的胃空期约30分钟的短时间母乳喂养中，母乳中PBDE的浓度和组成比也发生急剧变化。这一结果暗示了PBDEs在人体内积累的复杂作用。如上所述，本研究获得了一些宝贵的新发现。可以肯定的是，这些成果对于缓解未来人体污染、乳汁污染、环境污染、食品污染等的缓解措施有很大帮助。

项目成果

Investigation of the main source of polybrominated diphenylethers in human breast milk (The first report)

母乳中多溴二苯醚主要来源调查（第一份报告）

• 发表时间: 2005
• 期刊: Organohalogen Compounds 67
• 作者: Choi BK;Kawakami N;Chang SJ;Koh SB;Bjorner J;Punnett L;Karasek R.;Hideaki Miyata
• 通讯作者: Hideaki Miyata

Levels of PBDEs, TBBPA, TBPs, PCDDs/DFs, PXDDs/DFs and PBDDs/DFs in human milk of nursing women and dairy milk products in Japan

日本哺乳妇女母乳和乳制品中 PBDEs、TBBPA、TBPs、PCDDs/DFs、PXDDs/DFs 和 PBDDs/DFs 的含量

• 发表时间: 2004
• 期刊: Organohalogen Compounds 66
• 作者: Choi BK;Kawakami N;Chang SJ;Koh SB;Bjorner J;Punnett L;Karasek R.;Hideaki Miyata;Souichi Ohta
• 通讯作者: Souichi Ohta