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The mechanism of the higher brain function deterioration after cerebral apoplexy using the high field magnetic resonance diffusion tensor imaging.

利用高场磁共振扩散张量成像研究脑中风后高级脑功能恶化的机制。

基本信息

批准号：
14370445
负责人：
OGAWA Akira
金额：
$ 8.26万
依托单位：
Iwate Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2003
项目状态：
已结题

项目摘要

Increase in the bedridden patient after cerebral apoplexy has become a social problem in the this country though a death rate from the cerebrovascular disorder saw fixed repression with the medical progress. The mechanism of the higher brain function deterioration wasn't definite in comparison with the occurrence mechanism such as the limbs paralysis.As for this research, the elucidation of the higher brain function deterioration mechanism was done after the cerebral apoplexy. Magnetic resonance (MR) diffusion tensor images were adopted as a technique that an image evaluated the higher brain functional disorder. The fractional anisotropy (FA) value was used as the quantitative index of diffusion tensor. Preoperative FA values in the ipsilateral side were significantly lower than those in the contralateral side in the patients with chronic ischemic brain. After surgery, the FA value was significantly increased. Diffusion tensor imaging may indicate isehemic brain damage, not visualized by conventional MR imaging, in patients with chronic ischemic brain.This was connected with as well proving the clinical utility of the high field MR imaging.It was estimated with a brain perfusion image that how many cerebral blood flow declines were the range of the surgical medical treatment again. The amount of cerebral blood flow was greatly concerned with the higher brain function. The mechanism of the higher brain functional deterioration after cerebral apoplexy has been evaluated in this research.

随着医学的进步，脑血管病的死亡率有一定的下降，但脑卒中后卧床不起的患者增加已成为我国的一个社会问题。与肢体瘫痪等发生机制相比，脑卒中后高级脑功能衰退的机制尚不明确，本研究是在脑卒中后对脑卒中后高级脑功能衰退机制的阐明。采用磁共振（MR）弥散张量成像作为一种图像评价高级脑功能障碍的技术。各向异性分数（FA）值作为弥散张量的定量指标。慢性脑缺血患者术前同侧FA值明显低于对侧。术后FA值明显升高。扩散张量成像可以显示缺血性脑损伤，而不是通过常规MR成像，在慢性缺血性脑患者。这是连接以及证明高场MR成像的临床实用性。它是估计与脑灌注图像，多少脑血流量下降的范围内的外科医疗再次。脑血流量的多少与脑功能的高级化密切相关。本研究旨在探讨脑卒中后高级脑功能损害的机制。