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Research on the progression mechanism in arteriosclerotic lesion at the cervical and cerebral artery

Research on the progression mechanism in arteriosclerotic lesion at the cervical and cerebral artery
颈脑动脉粥样硬化病变进展机制的研究
批准号:
18390403
负责人:
OGAWA Akira
金额:
$10.02万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2006
资助国家:
日本
项目状态:
已结题
起止时间:
2006 至 2007

项目摘要

项目成果

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中文摘要
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英文摘要
OBJECTIVE: Approximately 20 to 30% of patients undergoing carotid endarterectomy (CEA) subsequently develop cognitive impairment The purpose of the present study is to determine whether or not malondialdehyde (MDA)-modified low-density lipoprotein (LDL), a biochemical marker of oxidative damage, concentrations in the jugular bulb during CFA correlates with development of postoperative cognitive impairment. METHODS: Fifty-five patients undergoing CEA were assessed with a battery of neuropsychological tests before and 1 month after surgery. Serum samples for measurement of MDA-LDL concentration were obtained from a venous catheter inserted into the ipsilateral jugular bulb at the following time points: immediately before clamping of the internal carotid artery (ICA), 10 minutes after clamping of the ICA, and 5 and 20 minutes after declamping of the ICA RESULTS: The MDA-LDL concentrations at 5 and 20 minutes after ICA declamping were both significantly higher than concentrations before IC … More Aclamping (P < 0.0001). At the postoperative neuropsychological assessment, six (11%) out of 55 patients showed postoperative cognitive impairment Logistic regression analysis demonstrated that higher values of MDA-LDL increase (calculated as a percentage of the preclamp values)at either 5 or 20 minutes after ICA declamping were significantly associated with the development of postoperative cognitive impairment(95% confidence interval, 0.787-0.981; P = 0.0209)among the variables tested. CONCLUSION: MDA-LDL concentration in the jugular bulb during CEA correlates with development of postoperative cognitive impairmentBACKGROUND AND PURPOSE: The purpose of the present study was to determine whether preoperative cerebral hemodynamic impairment and reactive oxygen species produced during carotid endarterectomy (CEA) correlate with development of postoperative cerebral hyperperfusion. METHODS: Concentrations of malondialdehyde-modified low-density lipoprotein (MDA-LDL), a biochemical marker of oxidative damage, were measured in serum samples obtained from 90 patients undergoing CEA for ipsilateral ICA stenosis (>70%). Serum samples were obtained from a venous catheter inserted into the ipsilateral jugular bulb before clamping of the internal carotid artery (ICA), 10 minutes after clamping of the ICA, and 5 and 20 minutes after declamping of the ICA. Cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) to acetazolamide were also measured using single-photon emission computed-tomography before CEA In addition, CBF was measured postoperatively. RESULTS: Hyperperfusion (CBF increase >100% compared with preoperative values)was observed immediately after CEA in 12 patients (13%). logistic regression analysis demonstrated that reduced preoperative CVR (95% CIs, 1.053 to 1.453; P=0.0097) and an increase in MDA-LDL (calculated as a percentage of the preclamp values) after. ICA declamping (95% Cis, 0.862 to 0.980; P=0.0098) were significantly associated with development of postoperative cerebral hyperperfusion among the variables tested. Ten of 11 patients with reduced preoperative CVR and increased MDA-LDL after ICA declamping developed post-CEA hyperperfusion, and 2 of these patients developed cerebral hyperperfusion syndrome. CONCLUSIONS: Both preparative cerebral hemodynamic impairment and reactive oxygen species produced during surgery correlate with development of cerebral hyperperfusion after CEA. Less
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会议论文
DOI: 10.3171/jns.2006.105.5.785
发表时间: 2006-11-01
期刊: JOURNAL OF NEUROSURGERY
影响因子: 4.1
作者: [Kubo, Yoshitaka, Ogasawara, Kuniaki, Ogawa, Akira]
通讯作者: Ogawa, Akira
DOI: --
发表时间: 2006
期刊: Neurologia medico-chirurgica 47
影响因子: --
作者: [Kuniaki, O, Kashimura H., Yamazaki T., Ishigaki D., Fukuda T., Kenji Y, Kashimura H., Ogawa a., Ogawa a., Suga Y., Saito H., Fujiwara S., Ogasawara K., Masanori K. et al., Takaaki B. et al., Hiroshi K. et al., Ogasawara K., Saito H., Komoribayashi N., Kashimura H.]
通讯作者: Kashimura H.
Bypass surgery revisited.-Japanese EC-IC bypass traial.The JET Study-
重新审视搭桥手术。-日本 EC-IC 搭桥试验。JET 研究-
DOI: --
发表时间: 2007
期刊:
影响因子: --
作者: [Akira, O, Ogawa A.]
通讯作者: Ogawa A.
Japanese EC-IC Bypass Trial: JET Syudy
日本 EC-IC 旁路试验:JET Syudy
DOI: --
发表时间: 2007
期刊:
影响因子: --
作者: [Akira, O, Ogawa A., Ogawa A., 小笠原 邦昭, 小川 彰, 小笠原 邦昭, 小笠原 邦昭, 小笠原 邦昭, 小笠原 邦昭, 小笠原 邦昭]
通讯作者: 小笠原 邦昭
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    Development of a method to non-invasively measure the brain temperature using diffusion tensor imaging
    • 批准号:
      23659696
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.16万
    • 财政年份:
      2011
    • 负责人:
      OGAWA Akira
    • 依托单位:
    The development of the new therapy aim to decrease the incidence of cerebrovascular disease based on suppression arterial sclerosis lesion.
    • 批准号:
      20390390
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $12.23万
    • 财政年份:
      2008
    • 负责人:
      OGAWA Akira
    • 依托单位:
    Development of diagnostics before cerebral apoplexy develops using super-high magnetic field MR imaging
    • 批准号:
      16390417
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $7.3万
    • 财政年份:
      2004
    • 负责人:
      OGAWA Akira
    • 依托单位:
    The mechanism of the higher brain function deterioration after cerebral apoplexy using the high field magnetic resonance diffusion tensor imaging.
    • 批准号:
      14370445
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $8.26万
    • 财政年份:
      2002
    • 负责人:
      OGAWA Akira
    • 依托单位:
    海外基金