Development of diagnostics before cerebral apoplexy develops using super-high magnetic field MR imaging

随着医学的进步，脑血管疾病的死亡率有一定的下降，但脑卒中后卧床不起的患者增加已成为我国的一个社会问题。此外，有很多病人即使没有死亡，也会陷入必要的护理状态。因此，认为社会对脑卒中前诊断的需求极高。本研究的目的是利用磁共振（MR）张量图像、灌注加权图像和高场MR波谱图像对脑卒中进行早期诊断，通过弥散张量图像对白色物质FA值的定量评价，可以对神经系统疾病进行定量评价。此外，不使用造影剂的完整非侵入性灌注图像建立了脑血流量和体积。该技术与SPECT图像具有良好的相关性。此外，弥散张量成像可在颅内出血的早期预测其运动功能的转归。在脑大动脉闭塞性疾病患者的常规MR波谱图像中，NAA值被认为是细胞代谢的指标，在发生变化之前，NAA值被发现降低。脑血管储备能力下降的病例是目前报道的脑卒中的高危人群。然而，脑血管储备能力没有方法，除了在核医学技术和评估它。有效地诊断患者的高危组从这个项目的结果，通过采取MR图像成为可能。MRI能安全、无创地筛查放射性照射的可能性，具有临床应用价值。

Increase in the bedridden patient after cerebral apoplexy has become a social problem in this country though a death rate from the cerebrovascular disorder saw fixed repression with the medical progress. Moreover, there are a lot of patients of falling into the state of the nursing necessary even if not becoming a death. Therefore, it is thought that the social need for the diagnosis is extremely high before the cerebral apoplexy. The aim of this project was to diagnose before cerebral apoplexy develops using magnetic resonance (MR) tensor, perfusion weighted and MR spectroscopic images scanned by high field MR imaging.It was shown to be able to evaluate the neurological disorder quantitatively as a result of this research by the quantitative evaluation of the FA value of white matter with the diffusion tensor image. Moreover, complete non-invasive perfusion images that did not use the contrast medium established cerebral blood flow and volume. The good correlation with SPECT images was shown in this technique. In addition, the outcome of their motor function could be predicted using diffusion tensor image at the early stage of the intracranial hemorrhage. The value of NAA assumed to be an index of the cell metabolizing was found decreasing before the change took place in a usual image in the patients with major cerebral artery occlusive disease for MR spectroscopy. The case that decreased cerebrovascular reserve capacity is the high-risk group patient of the cerebral apoplexy in a current report. However, cerebrovascular reserve capacity did not have the method except having in a nuclear medical technique and evaluating it. Efficiently diagnosing the patients in high-risk group became possible from the result of this project by taking MR images. MRI can screen the possibility of the radiation exposure none at all, and safely, and is clinical useful.