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Development of diagnostics before cerebral apoplexy develops using super-high magnetic field MR imaging

利用超高磁场磁共振成像开发脑中风诊断方法

基本信息

批准号：
16390417
负责人：
OGAWA Akira
金额：
$ 7.3万
依托单位：
Iwate Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390417/
关键词：
MRI MR spectroscopy Diffusion tensor imaging Super high magnetic field Pre-onset Perfusion weighted imaging Cerebral apoplexy 核酸テンソル MR spectroscopy

项目摘要

Increase in the bedridden patient after cerebral apoplexy has become a social problem in this country though a death rate from the cerebrovascular disorder saw fixed repression with the medical progress. Moreover, there are a lot of patients of falling into the state of the nursing necessary even if not becoming a death. Therefore, it is thought that the social need for the diagnosis is extremely high before the cerebral apoplexy. The aim of this project was to diagnose before cerebral apoplexy develops using magnetic resonance (MR) tensor, perfusion weighted and MR spectroscopic images scanned by high field MR imaging.It was shown to be able to evaluate the neurological disorder quantitatively as a result of this research by the quantitative evaluation of the FA value of white matter with the diffusion tensor image. Moreover, complete non-invasive perfusion images that did not use the contrast medium established cerebral blood flow and volume. The good correlation with SPECT images was shown in this technique. In addition, the outcome of their motor function could be predicted using diffusion tensor image at the early stage of the intracranial hemorrhage. The value of NAA assumed to be an index of the cell metabolizing was found decreasing before the change took place in a usual image in the patients with major cerebral artery occlusive disease for MR spectroscopy. The case that decreased cerebrovascular reserve capacity is the high-risk group patient of the cerebral apoplexy in a current report. However, cerebrovascular reserve capacity did not have the method except having in a nuclear medical technique and evaluating it. Efficiently diagnosing the patients in high-risk group became possible from the result of this project by taking MR images. MRI can screen the possibility of the radiation exposure none at all, and safely, and is clinical useful.

尽管随着医学的进步，脑血管疾病的死亡率得到了一定程度的抑制，但脑中风后卧床病人的增加已成为该国的一个社会问题。另外，即使没有死亡，也有很多患者陷入了需要护理的状态。因此，认为脑中风发生前的社会诊断需求极高。该项目的目的是利用磁共振（MR）张量、灌注加权和高场MR成像扫描的MR光谱图像在脑中风发生前进行诊断。通过用扩散张量图像定量评估白质的FA值，本研究的结果表明能够定量评估神经系统疾病。此外，不使用造影剂的完整无创灌注图像确定了脑血流量和容量。该技术显示出与 SPECT 图像的良好相关性。此外，可以利用颅内出血早期的弥散张量图像来预测其运动功能的结果。在患有主要脑动脉闭塞性疾病的患者的磁共振波谱分析中，发现NAA值在发生变化之前就被认为是细胞代谢的指标而下降。该例脑血管储备能力下降的病例是目前报道的脑中风高危人群患者。然而，脑血管储备能力除了通过核医学技术进行评价外，没有其他方法。该项目的结果使得通过拍摄 MR 图像对高危人群进行有效诊断成为可能。 MRI可以筛查完全没有辐射暴露的可能性，并且安全，并且在临床上有用。

项目成果

期刊论文数量（16）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Minute glioma identified by 3.0 tesla magnetic resonance spectroscopy.

通过 3.0 特斯拉磁共振波谱鉴定微小胶质瘤。

DOI：
发表时间：
2005
期刊：
Neurol Med Chir (Tokyo) 45
影响因子：
0
作者：
Honmou;O;Endo H et al.;Kashimura H et al.;Inoue T et al.;Beppu T et al.;Inoue T et al.
通讯作者：
Inoue T et al.

Curved planar reformation法による中心溝同定の脳神経外科臨床応用に関する研究.

曲面平面重建法中央沟识别在神经外科中的临床应用研究

DOI：
发表时间：
期刊：
(岩手医学雑誌掲載予定)
影响因子：
0
作者：
Ogasawara K;et al.;Inoue T et al.;Inoue T et al.;Ogasawara K et al.;Ogasawara K et al.;Ogasawara K et al.;西本英明他
通讯作者：
西本英明他

Delayed cerebral hyperperfusion syndrome caused by prolonged impairment of cerebrovascular autoregulation after carotid endarterecto

颈动脉内膜切除术后脑血管自动调节长期受损所致迟发性脑过度灌注综合征