Development of diagnostics before cerebral apoplexy develops using super-high magnetic field MR imaging

随着医学的进步，脑血管疾病的死亡率呈固定的下降趋势，但脑卒中后卧床病人的增加已成为我国的一个社会问题。而且，有很多病人陷入了护理的必要状态，即使没有成为死亡。因此，人们认为社会对脑卒中前诊断的需求是非常高的。本研究的目的是利用高场磁共振成像扫描的磁共振张量、灌注加权和磁共振光谱图像，在脑卒中发展之前进行诊断。本研究结果表明，通过弥散张量图像定量评价白质FA值，可以定量评价神经系统疾病。此外，不使用造影剂的完整无创灌注图像确定了脑血流量和脑容量。结果表明，该方法与SPECT图像具有良好的相关性。此外，弥散张量图像在颅内出血早期可以预测其运动功能的预后。作为细胞代谢指标的NAA值在脑大动脉闭塞症患者的磁共振成像中，在正常图像发生变化之前就开始下降。脑血管储备能力下降的病例是目前报道的脑卒中高危人群。然而，脑血管储备容量除在核医学技术中有及评价外，没有其他方法。该项目的结果使通过磁共振成像对高危人群进行有效诊断成为可能。核磁共振成像可以完全安全地筛查辐射暴露的可能性，并且具有临床应用价值。

Increase in the bedridden patient after cerebral apoplexy has become a social problem in this country though a death rate from the cerebrovascular disorder saw fixed repression with the medical progress. Moreover, there are a lot of patients of falling into the state of the nursing necessary even if not becoming a death. Therefore, it is thought that the social need for the diagnosis is extremely high before the cerebral apoplexy. The aim of this project was to diagnose before cerebral apoplexy develops using magnetic resonance (MR) tensor, perfusion weighted and MR spectroscopic images scanned by high field MR imaging.It was shown to be able to evaluate the neurological disorder quantitatively as a result of this research by the quantitative evaluation of the FA value of white matter with the diffusion tensor image. Moreover, complete non-invasive perfusion images that did not use the contrast medium established cerebral blood flow and volume. The good correlation with SPECT images was shown in this technique. In addition, the outcome of their motor function could be predicted using diffusion tensor image at the early stage of the intracranial hemorrhage. The value of NAA assumed to be an index of the cell metabolizing was found decreasing before the change took place in a usual image in the patients with major cerebral artery occlusive disease for MR spectroscopy. The case that decreased cerebrovascular reserve capacity is the high-risk group patient of the cerebral apoplexy in a current report. However, cerebrovascular reserve capacity did not have the method except having in a nuclear medical technique and evaluating it. Efficiently diagnosing the patients in high-risk group became possible from the result of this project by taking MR images. MRI can screen the possibility of the radiation exposure none at all, and safely, and is clinical useful.