Development of diagnostics before cerebral apoplexy develops using super-high magnetic field MR imaging

在这个国家，中风后卧床患者的增加已经成为一个社会问题，尽管随着医学的进步，脑血管疾病的死亡率受到了固定的抑制。此外，还有很多患者陷入必要的护理状态，即使不是死亡。因此，人们认为中风前对诊断的社会需求极高。该项目的目的是利用磁共振(MR)张量、灌注加权和高场MR扫描的MR波谱图像在中风发生之前进行诊断。结果表明，通过扩散张量图像对脑白质FA值的定量评估，能够定量评估本研究的结果所致的神经功能障碍。此外，没有使用造影剂的完整的非侵入性血流灌注图像确定了脑血流量和容量。该技术与SPECT图像具有良好的相关性。此外，在颅内出血的早期阶段，利用扩散张量成像可以预测其运动功能的转归。在主要脑动脉闭塞性疾病患者的磁共振波谱图中，通常认为是细胞代谢指标的NAA值在改变发生之前就降低了。脑血管储备能力下降是目前报道的脑卒中高危人群。然而，脑血管储备能力除了有核医学技术并对其进行评估外，还没有方法。通过对高危人群进行磁共振成像，对高危人群进行有效的诊断成为可能。MRI对辐射暴露的可能性进行筛查，完全不存在，而且安全可靠，具有临床实用价值。

Increase in the bedridden patient after cerebral apoplexy has become a social problem in this country though a death rate from the cerebrovascular disorder saw fixed repression with the medical progress. Moreover, there are a lot of patients of falling into the state of the nursing necessary even if not becoming a death. Therefore, it is thought that the social need for the diagnosis is extremely high before the cerebral apoplexy. The aim of this project was to diagnose before cerebral apoplexy develops using magnetic resonance (MR) tensor, perfusion weighted and MR spectroscopic images scanned by high field MR imaging.It was shown to be able to evaluate the neurological disorder quantitatively as a result of this research by the quantitative evaluation of the FA value of white matter with the diffusion tensor image. Moreover, complete non-invasive perfusion images that did not use the contrast medium established cerebral blood flow and volume. The good correlation with SPECT images was shown in this technique. In addition, the outcome of their motor function could be predicted using diffusion tensor image at the early stage of the intracranial hemorrhage. The value of NAA assumed to be an index of the cell metabolizing was found decreasing before the change took place in a usual image in the patients with major cerebral artery occlusive disease for MR spectroscopy. The case that decreased cerebrovascular reserve capacity is the high-risk group patient of the cerebral apoplexy in a current report. However, cerebrovascular reserve capacity did not have the method except having in a nuclear medical technique and evaluating it. Efficiently diagnosing the patients in high-risk group became possible from the result of this project by taking MR images. MRI can screen the possibility of the radiation exposure none at all, and safely, and is clinical useful.