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Recovery mechanism of lower urinary tract function and changes of the neurotransmitter levels in the lumbosacral cord according to cerebrospinal damage

脑脊髓损伤后下尿路功能恢复机制及腰骶神经递质水平变化

基本信息

批准号：
14370516
负责人：
SUGAYA Kimio
金额：
$ 5.7万
依托单位：
University of the Ryukyus
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

项目摘要

1.Comparison of the neural mechanisms in the lumbosacral cord about the inhibition of micturition by stimulation of the pontine reticular formation or the perineum in rats. : The glycine and serine levels in the lumbosacral cord were increased when the bladder contraction was inhibited by stimulation of the pontine reticular formation, while the glycine level was increased but the serine level did not change in the lumbosacral cord when the bladder contraction was inhibited by stimulation of the perineum. This difference was considered because the metabolisms of the glycinergic neurons in the lumbosacral cord were also activated by stimulation of the pontine reticular formation.2.The relation of the noradrenargic projection to the lumbosacral cord and amino acid neuronal activities in rats. : There were inhibitory neurons having the alpha-1D receptors in the lumbosacral cord. When these neurons received noradrenergic inputs, these neurons inhibited glycinergic neurons and urinary frequency occurred, but much noradrenergic inputs inhibited bladder contraction by inhibition of the afferent limb of the micturition reflex.3.The improvement effect of the overactive bladder by glycine and/or GABA diet. : One % glycine diet for 4 weeks inhibited bladder and urethral activities in rats with/without spinal cord injury. Effect of glycine and GABA diet was uncertain. Therefore, it may be possible that the glycine is used for treatment of overactive bladder.

1.刺激脑桥网状结构和会阴抑制大鼠排尿的腰骶髓神经机制比较。刺激脑桥网状结构抑制膀胱收缩时，腰骶髓中甘氨酸和丝氨酸水平升高;刺激会阴抑制膀胱收缩时，腰骶髓中甘氨酸水平升高，丝氨酸水平无变化。这可能是因为刺激脑桥网状结构也能激活腰骶髓甘氨酸能神经元的代谢活动。2.大鼠腰骶髓去甲肾上腺素能投射与氨基酸神经元活动的关系。腰骶髓内存在具有α-1D受体的抑制性神经元。当这些神经元接受去甲肾上腺素能输入时，这些神经元抑制甘氨酸能神经元，出现尿频，但大量去甲肾上腺素能输入通过抑制排尿反射的传入支抑制膀胱收缩。3.甘氨酸和/或GABA饮食对膀胱过度活动症的改善作用。：1%甘氨酸饮食4周抑制脊髓损伤和无脊髓损伤大鼠的膀胱和尿道活动。甘氨酸和GABA饮食的影响尚不确定。因此，甘氨酸可能用于治疗膀胱过度活动症。