The molecular analyses of Cadherin-11 and periostin regulating osteoblast differentiation

Cadherin-11和periostin调节成骨细胞分化的分子分析

• 批准号: 14370590
• 负责人: KUDO Akira
• 金额: $ 8.96万
• 依托单位: Tokyo Institute of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14370590/
• 关键词: Cadherin-11; Osteo-linegae; Teratoma; mesenchymal cells; 骨芽細胞; ペリオスチン; メカニカルストレス

We studied Cadherin-11 function in the differentiation of osteoblasts.Teratomas harbouring the Cadherin-11 gene generated bone and cartilage preferentially. Cadherin-11 transfectants of C2C12 cells and Cadherin-11 and/or N-cadherin transfectants of L cells demonstrated that Cadherin-11.

我们研究了钙粘附素-11在成骨细胞分化中的作用。携带钙粘附素-11基因的畸胎瘤优先生成骨和软骨。C2C12细胞的钙粘附素-11和L细胞的钙粘附素-11和/或N-钙粘附素的转染体证实了钙粘附素-11的表达。

项目成果

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Kaifu, T.、Nakahara, J.、Inui, M.、Mishima, K.等人：“DAP12 缺陷型小鼠中骨质疏松症和丘脑髓鞘减少症伴突触变性”J.Clin.Invest.. 111. 323-332（

Momoi, A.: "Analysis of Wnt8 for neural posteriorizing factor by identifying Frizzled 8c and Frizzled 9 as functional receptors for Wnt8"Mech.Dev.. 120. 477-489 (2003)

Momoi, A.：“通过将 Frizzled 8c 和 Frizzled 9 识别为 Wnt8 的功能受体来分析 Wnt8 的神经后验因子”Mech.Dev.. 120. 477-489 (2003)

Hirose, Y., Suzuki, H., Amizuka, N., Shimomura, J., Kawano, Y., Nozawa-Inoue, K., Kudo, A., Maeda, T.: "Immunohistochemical localization of periostin in developing long bones of mice."Biomedical Res.. 24. 31-37 (2003)

Hirose，Y.，Suzuki，H.，Amizuka，N.，Shimomura，J.，Kawano，Y.，Nozawa-Inoue，K.，Kudo，A.，Maeda，T.：“骨膜素在发育长过程中的免疫组织化学定位

Nagaya, M.: "Expression of zisp, a DHHC zinc finger gene, in somites and lens during zebrafish embryogenesis."Mech.Dev.. 119S. S311-S314 (2002)

Nagaya, M.：“在斑马鱼胚胎发生过程中，DHHC 锌指基因 zipp 在体节和晶状体中的表达。”Mech.Dev.. 119S。