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Assessment of corrosive properties of dental alloys in terms of interaction between organic acids comprised in human's mixed saliva

根据人类混合唾液中有机酸之间的相互作用评估牙科合金的腐蚀性能

基本信息

批准号：
14370639
负责人：
FUJII Hiroyuki
金额：
$ 6.66万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

项目摘要

Using immersion solusion containing organic acids in human's whole saliva or their mixed solusion, some dental materials had been evaluated their characteristics in terms of biocompatibility, and in order to obtained available data for interpretation of clinical phenomena in dental material allergy.1.In resting whole saliva of normal subjects, citric, pyrubic, malic, succinic, lactic, formic, acetic, propionic and carbonic acids were decteted, and their mean concentration were 3.29,0.07,0.03,0.02,0.49,0.27,1.88,0.17 and 7.91 in mM, respectively.2.Metal elements were detected in 60 out of 81 cosmetic products and in 39 out of 50 household products. In the largest group of products tested, i.e., make-upproducts, Fe was detected in all 23 samples(100%), and Ti and Zn were in 20(87%) and 19(83%) products, respectively. The metal elements contained in the cosmetic products were K,Ca,Ti,Fe,Zn and Bi,and in household products were K,Ca,Fe,Cu,and Zn.3.Six allergenic ingredients(methyl methacrylate, hydroquinone, formaldehyde, benzoyl peroxide, benzoic acid and methyl benzoate) were detected in a eluate from the old denture base resin used for a period of nearly 30 years.4.Immersion test using ICP-MS showed the dissolution of metal elements of Pt and Pd from the mixed solusion of organic acids comprised in human saliva (7.13 mM) in which specimens of dental casing alloys (Type IV gold-Pt alloy and Pd alloy) had been immersed for 3 weeks.

采用含有机酸的全唾液浸泡溶液或混合溶液，评价了一些牙用材料的生物相容性特征，以期为解释牙用材料过敏的临床现象提供数据依据。正常人静息全唾液中检测到柠檬酸、丙酮酸、苹果酸、琥珀酸、乳酸、甲酸、乙酸、丙酸和碳酸，其平均浓度分别为3.29、0.07、0.03、0.02、0.49、0.27、1.88、0.17和7.91。81种化妆品中有60种，50种家用产品中有39种检测出金属元素。在测试的最大产品组，即化妆品中，所有23个样品中都检测到铁（100%），20个（87%）和19个（83%）样品中分别检测到Ti和Zn。化妆品中的金属元素为K、Ca、Ti、Fe、Zn和Bi，家用产品中的金属元素为K、Ca、Fe、Cu和Zn.3。从使用近30年的旧义齿基托树脂洗脱液中检测出6种致敏成分（甲基丙烯酸甲酯、对苯二酚、甲醛、过氧化苯甲酰、苯甲酸和苯甲酯）。ICP-MS浸泡试验表明，牙套合金（IV型金-铂合金和钯合金）试样在人唾液（7.13 mM）中含有机酸的混合溶液中浸泡3周后，金属元素Pt和Pd有溶解。