Assessment of corrosive properties of dental alloys in terms of interaction between organic acids comprised in human's mixed saliva

本研究采用含有机酸的人全唾液浸泡液或其混合液，对口腔材料的生物相容性进行了评价，为口腔材料过敏的临床研究提供依据：1.在正常人的静息全唾液中，检测了柠檬酸、丙酮酸、苹果酸、琥珀酸、乳酸、甲酸、乙酸、丙酸和碳酸。2.在81种化妆品和50种日用品中，分别有60种和39种检出金属元素，其平均浓度分别为3.29、0.07、0.03、0.02、0.49、0.27、1.88、0.17和7.91mM。在测试的最大一组产品中，即，在化妆品中，23个样品（100%）中检测到Fe，20个（87%）和19个（83%）产品中分别检测到Ti和Zn。化妆品中含有的金属元素为K、Ca、Ti、Fe、Zn、Bi，日用品中含有的金属元素为K、Ca、Fe、Cu、Zn（甲基丙烯酸甲酯，氢醌，甲醛，过氧化苯甲酰，苯甲酸和苯甲酸甲酯）在使用了近30年的旧义齿基托树脂中检测到。MS显示Pt和Pd的金属元素从人唾液（7.13mM）中包含的有机酸的混合溶液中溶解，其中牙科壳体合金（IV型金-Pt合金和Pd合金）的样品已经在人唾液中浸泡了3周。

Using immersion solusion containing organic acids in human's whole saliva or their mixed solusion, some dental materials had been evaluated their characteristics in terms of biocompatibility, and in order to obtained available data for interpretation of clinical phenomena in dental material allergy.1.In resting whole saliva of normal subjects, citric, pyrubic, malic, succinic, lactic, formic, acetic, propionic and carbonic acids were decteted, and their mean concentration were 3.29,0.07,0.03,0.02,0.49,0.27,1.88,0.17 and 7.91 in mM, respectively.2.Metal elements were detected in 60 out of 81 cosmetic products and in 39 out of 50 household products. In the largest group of products tested, i.e., make-upproducts, Fe was detected in all 23 samples(100%), and Ti and Zn were in 20(87%) and 19(83%) products, respectively. The metal elements contained in the cosmetic products were K,Ca,Ti,Fe,Zn and Bi,and in household products were K,Ca,Fe,Cu,and Zn.3.Six allergenic ingredients(methyl methacrylate, hydroquinone, formaldehyde, benzoyl peroxide, benzoic acid and methyl benzoate) were detected in a eluate from the old denture base resin used for a period of nearly 30 years.4.Immersion test using ICP-MS showed the dissolution of metal elements of Pt and Pd from the mixed solusion of organic acids comprised in human saliva (7.13 mM) in which specimens of dental casing alloys (Type IV gold-Pt alloy and Pd alloy) had been immersed for 3 weeks.